摘要
结肠因具有特殊的生理环境而特别适于作为某些特殊疾病和药物治疗的靶向器官。近年,结肠靶向给药系统在制剂学和靶向材料研究等方面取得了较大进展。口服结肠靶向给药系统的制备技术主要可分为生物黏附技术、前体药物技术、包衣技术、胶囊化技术、微粒技术、骨架技术等。本文综述了结肠靶向给药制备技术的最新研究进展,以期为结肠靶向给药制剂的制备提供参考。
Colon can be used as the target organ for treating certain specific diseases for its special physiological environment. In recent years, great progress had been made in colon-specific drug delivery system, focused on pharmaceutics and targeted materials. The preparation techniques of oral colon-specific drug delivery system include bio-adhesion technology, pro-drug technology, coating methods, encapsulation methods, microencapsulation technique and matrix technology. This article reviewed the latest research on preparation technology of colon targeted drug delivery system, which could provide reference for preparing colon targeted drug delivery formulations.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2014年第16期1868-1874,共7页
Chinese Journal of New Drugs
基金
国家"重大新药创制"科技重大专项(2014ZX09507005-002)
关键词
结肠靶向给药
生物黏附技术
前体药物技术
包衣技术
胶囊化技术
colon targeted drug delivery
bio-adhesion technology
pro-drug technology
coating methods
encapsulation methods
