低强度超声丹参透入疗法对骨折愈合影响的实验研究

The Effects of Fracture Healing Following by Low Intensity Pulsed Ultrasound Associated with Danshen Phonophoresis an experimental study

目的:观察低强度超声丹参透入疗法对骨折愈合的影响。方法:45只新西兰大耳白兔,人为造成右桡骨中段3mm骨质缺损作为骨折模型,随机分为3组:超声波治疗组(超声组),超声波联合外用丹参治疗组(实验组)和对照组(不做任何治疗),分别在术后2、4、6周行X线检查,进行评分,同时观察比较X线片骨痂灰度值。对部分骨折组织行组织病理检查,从组织学角度观察分析骨折愈合情况。结果:X线检查结果显示实验组骨折愈合较超声组和对照组均提前。术后2、4、6周时X线评分值,X线骨痂灰度值,实验组均高于超声组和对照组(P<0.01)。组织病理结果显示,实验组在机化血肿,纤维、软骨、骨性骨痂生长等方面都优于对照组和超声组。结论:超声波丹参透入疗法对骨折愈合有较好的促进作用。

Obj ective：To explored the role of bone healing at different stages after treatment with low intensity pulse ultrasound associated with danshen phonophoresis.Methods：45 New Zealand white rabbits were randomly divided into three groups the ultrasound group（only using low intensity pulse ultrasound）the research group（low intensity pulse ultrasound associated with danshen phonophoresis） and the control group（with sham treatment）.All rabbits were fractured at right middle radial bone with the same procedure.The X-ray sx-amination and histological examination were conducted for 2 week,4 weeks and 6 weeks after operation respectively.The X-ray score and his-tological sample were analyzed.Results：Compared with the ultrasound group and the control group,the X-ray had significnatly improved in the research group after different time of operation （P〈0.01）.Copmared with the control group and the ultrasound group,the histological examination had obviously improved in organization of hematoma,fibrous j oint,woven bone formation and lamellar bone formation in the research group.Conclusion：Low intensity pulse ultrasound associated with danshen phonophoresis had greater improvement effects on bone healing.