脑心通胶囊和瑞舒伐他汀对脑梗死合并颈动脉粥样斑块患者的血脂及血液流变学的影响

Effect of naoxintong capsules combined with rosuvastatin on blood lipid and blood rheology of patients with cerebral infarction combined with carotid atheromatous plaque

目的探讨脑心通胶囊和瑞舒伐他汀对脑梗死合并颈动脉粥样斑块患者的血脂及血液流变学的影响。方法将104例脑梗死合并颈动脉粥样斑块患者随机均分为对照组和治疗组,对照组采用瑞舒伐他汀(10 mg/d,1次/d)进行治疗,治疗组在对照组的基础上,给予脑心通胶囊(1.2 g/次,3次/d)治疗,两组治疗周期均为6个月,对比两组治疗前后的血脂、血液流变学指标变化。结果两组治疗后的TC、TG、LDL-C、HDLC与治疗前比较差异均有统计学意义(P<0.05),治疗后治疗组TC、TG、LDL-C、HDL-C值与对照组比较差异具有统计学意义(P<0.05);治疗后,两组的血液流变学指标均出现明显的下降(P<0.05),治疗组血液流变学指标变化值大于对照组(P<0.05);两组治疗后的总动脉IMT、颈动脉斑块积分、NIHSS评分、MRS评分较治疗前明显降低,而Barthel指数明显上升,治疗组治疗前后的IMT、颈动脉斑块积分、NIHSS评分、MRS评分及Barthel指数差值明显大于对照组(P<0.05)。结论脑心通胶囊和瑞舒伐他汀能明显改善脑梗死合并颈动脉粥样斑块患者的血脂及血液流变学指标,降低总胆固醇、三酰甘油、低密度脂蛋白胆固醇水平,稳定动脉粥样硬化斑块,改善脑功能。

Objective To explore the effect of naoxintong capsules combined with rosuvastatin on blood lipid and blood rheology of patients with brain infarction combined with carotid atheromatous plaque. Methods 104 patients with brain infarction complicated with carotid atheromatous plaque were randomly and equally divided into control group and treatment group, control group was given rosuvastatin （10 mg/d, once daily） , on the basis of the control group, the treatment group was given naoxintong capsules （ 1.2 g per time, 3 times daily）, with treatment period of six months of the two groups, blood lipid and blood rheology indexes before and after treatment in two groups were ob- served. Results TC,TG,LDL-C,HDL-C of the two groups after treatment had obvious difference from those before treatment（P 〈0. 05 ）, after treatnent there were significant differences in TC, TG, LDL-C, HDL-C between the two groups （ P 〈 0. 05 ）. After treatment, blood theology indexes of the two groups obviously decreased （ P 〈 0. 05 ） , hemo- rheology index change values of the treatment group were respectively greater than those of control group （ P 〈 0. 05 ）. In the two groups the total artery IMT and carotid plaque integral, NIHSS score, MRS score after treatment were signifi- cantly lower, and Barthel index increased obviously, significart difference was observed in IMT and carotid plaque integral, NIHSS score, MRS score and Barthel index between the two groups （ P 〈 0. 05 ）. Conclusion Naoxintong capsule and rosuvastatin can obviously improve the blood lipid and blood rheology indexes, lower TC, TG, LDL-C, make atherosclerotic plaque stability, improve brain function of patients with cerebral infarction complicated with carotid atheromatous plaque.