小麦纤维素对比乳果糖在儿童功能性便秘中的临床应用

Clinical value of fiberform compared with lactulose in the treatment of functional constipation in children

目的探讨小麦纤维素对比乳果糖在儿童功能性便秘中的近期临床治疗价值和停药后的复发情况。方法对2012年1月至2013年12月在我院门诊就诊的135例功能性便秘患儿,根据家属意愿选择分为纤维素组45例、乳果糖组48例和对照组42例,纤维素组口服小麦纤维素加思连康,乳果糖组口服乳果糖加思连康,对照组口服思连康,观察用药2周的临床效果和停药2周后的复发情况。结果纤维素组有效42例,复发9例;乳果糖组有效30例,复发22例;对照组有效9例,复发6例,经统计学检验,三组之间治疗效果差异有统计学意义(P<0.05),纤维素组效果优于乳果糖组和对照组,乳果糖组优于对照组。复发情况比较,纤维素组低于乳果糖组和对照组(P<0.05),乳果糖组和对照组比较差异无统计学意义(P>0.05)。结论小麦纤维素对比乳果糖治疗儿童功能性便秘近期效果显著,停药后复发少,值得临床应用。

Objective To study the therapeutic value of fiberform in treatment of functional constipation and the recurrence after stopping drugs in children. Methods 135 cases of functional constipation children in our hospital, according to the results of the parents＇ requirements, 45 cases were defined as fiberform group, 48 cases as lactulose group and 42 cases as control group. Control group was given probiotics preparation （siliankang） ; besides siliankang, fiberform or lactulose were applied in combination separately in fiberform group and lactulose group. Results There were 42 effective cases and 9 recurrent cases in fiberform group;30 effective cases and 22 recurrent cases in lactulose group;9 effective cases and 6 recurrent cases in the control group. Significant differences were found between the con- trol group and the other two groups （ P 〈 0. 05 ）, and the therapeutic effect in fiberform group was obviously superior to that in lactulose group（ P 〈 0. 05 ）. Recurrence rate of constipation in fiberform group was lower than that in the other two groups （ P 〈 0. 05 ）. There was no significant difference between lactulose group and control group （ P 〉 O. 05 ）. Conclusion Fiberform is more effective than lactulose in short-term treatment of functional constipation in children, the recurrence rate is low.