摘要
以(S)-2-氨基丁酰胺、衣康酸二甲酯为起始原料经环合、还原、磺酰化、取代、还原、取代六步反应得到(s)-2-N-[4-(2-溴乙酰基)胺基乙基-2-氧基吡咯烷酮]丁酰胺。反应总收率为10.7%。目标化合物的结构经MS,1H-NMR确证。该化合物合成难度大,工艺需进一步优化。
The substance which is an important medicine intermediate of antiepileptic drugs was obtained from （S）-2-aminobutanamide and dimethylitaconate via cycloaddition,reduction,sulfonylation,substitution,reduction,substitution six reactions.The total yields of six reactions was 10.7％.The structure of them were confirmed by element analysis,MS,1 H-NMR.The synthetic route for medicine intermediate is great diffcuhy.The synthetic technics is further optimized.
出处
《科学技术与工程》
北大核心
2014年第22期257-259,共3页
Science Technology and Engineering
关键词
抗癫痫药物
丁酰胺
合成
antiepileptic drugs
butanamide modulator
synthesis
