当归药材安全性的灰色关联度评价

Safety Evaluation of Angelicae Sinensis Radix by Grey Incidence Degree Method

目的：建立当归药材安全性的灰色关联度模型并进行安全性评价。方法：测定不同产地当归药材中总灰分、酸不溶性灰分以及铅、镉、砷、汞、铜5种有害重金属元素含量,以定义的相对关联度为测度,采用DPS V 7.0.5统计软件构建当归药材安全性的灰色关联度评价模型。结果：各评价单元序列的相对关联度在0.380 5～0.600 0,相对关联度〈0.500 0的样本共有25批,这些样本的安全性较好,主要是甘肃岷县、渭源县、漳县以及云南所产的当归样本;相对关联度排名在前25名的样本中,甘肃岷县产有9批,甘肃渭源县产有3批,甘肃漳县产有3批,云南产有4批,分别占各自产地样本总数的90.0%,50.0%,60.0%,100%;通过该模型得到的结论与当归药材的道地性内涵相一致。结论：该方法及模型可推广应用于当归药材的安全性评价。

Objective： The study was conducted to establish the method of degree incidence and to evaluate the safety of Angelicae Sinensis Radix from different habitats. Method： The contents of total ash,acid insoluble ash,Pb,Cd,As,Hg,and Cu in Angelicae Sinensis Radix were determined. The grey model was established by DPS V7. 0. 5 statistical software via the measurement of relative incidence degree. Result： The relative incidence degrees of all evaluation items were between 0. 380 5-0. 600 0; totally the relative incidence degrees from 25 batches of Angelicae Sinensis Radix were less than 0. 500 0,which had better safety,including 9batches from Min County,Gansu Province,3 batches from Weiyuan County,Gansu Province,3 batches from Zhang County,Gansu Province,and 4 batches from Yunnan Province,accounting for 90. 0%,50. 0%,60. 0%,and 100% of the total number of their samples,respectively. The results based on the established model showed that the evaluation results were consistent with the genuineness meaning of Angelicae Sinensis Radix. Conclusion：This method and model can be well used to evaluate the safety of Angelicae Sinensis Radix.