基于中医传承辅助系统治疗骨转移方剂组方规律分析

Analysis on Composition Principles of Prescriptions for Bone Metastases by Using Traditional Chinese Medicine Inheritance System

目的:基于中医传承辅助系统软件,探索骨转移癌内服方剂的组方规律。方法:收集、整理中国学术期刊全文数据库(CNKI)中治疗骨转移癌的内服方剂,录入中医传承辅助系统,利用软件集成的熵层次聚类方法进行组方规律分析。结果:对筛选出的43个方剂进行分析,确定方剂中药物出现的频次,演化得到核心组合29个、新处方8个。8个新处方中有7个涵盖补正扶虚药物。补骨脂-淫羊藿-桂枝-香附,补骨脂-骨碎补-桂枝-香附,补骨脂-骨碎补-杜仲-茯苓为较常用的核心处方,方中重用归肾经的补骨脂、骨碎补、淫羊藿3味药,出现频次高,且两两之间及3药整体都表现出高度关联。结论:中医传承辅助系统软件同时实现以频次为核心的显性经验分析和以关联为核心的隐性经验分析,体现了"多元融合"的传承研究模式,客观地总结了骨转移癌内服方剂的组方规律,以扶正补虚为基本治则,从肾论治骨转移癌。为临床应用提供有益的探索与参考。

Objective： To analyze the composing principles of prescriptions for bone metastases with traditional Chinese medicine（TCM） inheritance system. Method： The prescriptions used for bone metastases from China National Knowledge Infrastructure（CNKI） database were collected,the composing principles were analyzed using hierarchical clustering method in the TCM inheritance system after data entry. Result： Based on the analysis on 43 cases of prescriptions were mined from the database which come up with 29 core medicine pairs and eight new formulas. Seven of the eight new formulas contained tonic herbs. Psoraleae Fructus-Epimedii Folium-Cinnamomi Ramulus-Cyperi Rhizoma,Psoraleae Fructus-Drynariae Rhizoma-Cinnamomi Ramulusi-Cyperi Rhizoma,Psoraleae Fructus-Drynariae Rhizoma-Eucommiae Cortex-Poria were widely used Psoraleae Fructus, Drynariae Rhizoma,Epimedii Folium,which belonged to kidney channel,were in high frequency and showed a high-level association as a whole. Conclusion： TCM inheritance system provides an important method in exploring the composing principles for bone metastases through obtaining frequency of dominant empirical analysis as well as association of implicit empirical analysis. The basic therapeutic principle strengthening the body resistance and using kidney channel herbs provides available exploration and is beneficial for clinical use.