个体化心理干预对乳腺癌患者免疫功能和不良情绪评分的影响

Influence of individual psychological intervention on immune function and bad mood score of patients with breast cancer

目的研究个体化心理干预对乳腺癌患者免疫功能和不良情绪的影响。方法将102例乳腺癌患者按住院治疗的先后顺序随机分为观察组、对照组各51例。对照组给予常规护理,观察组在常规护理的基础上实施个体化心理干预。采用焦虑自评量表(SAS)、抑郁自评量表(SDS)和症状自评量表(SCL-90)对患者进行心理状况评价;采用放免法测定患者外周血中白细胞介素-2(IL-2)、白细胞介素-4(IL-4)和肿瘤坏死因子(TNF-γ)含量。结果心理干预后,观察组患者的焦虑、抑郁程度和SCL-90中躯体化、强迫、人际关系、抑郁、焦虑、恐怖及偏执因子得分均显著低于对照组(P<0.01);IL-2和TNF-γ含量均明显高于对照组(均P<0.01)。结论个体化心理干预,可有效减轻患者的不良情绪,提高患者机体免疫功能,对患者的治疗康复有着重要作用。

[ Objective] To study the influence of individual psychological intervention on immune function bad mood score of patients with breast cancer. [Methods] 102 cases of breast cancer patients were randomly divided into observation group and control group according to the order of hospitalization, 51 cases in each group. The control group was given conventional nursing, the observation group was given individual psychological intervention on the basis of routine care. The Self Rating Anxiety Scale （ SAS）, Self Rating Depression Scale （ SDS ） and Symptom Checklist 90 （ SCL-90 ） were adopted to evaluate the mental status of patients ; the radioimmunoassay method was adopted to detect the content of IL-2, IL- 4 and TNF-γin peripheral blood. [ Results ] After the psychological intervention, the degree of anxiety and depression, the scores of somatization, compulsion, interpersonal relationship, depression, anxiety, terror and paranoia in observation group were significantly lower than those in control group （P 〈0.01）, the content of IL-2 and TNF-γ were significantly higher than those in control group （ P 〈 0.01 ）. [ Conclusion] Individual psychological intervention can effectively reduce the bad emotion of patients, improve the immune function, plays an important role in the treatment and rehabilitation of patients.