大容量全肺灌洗术对尘肺患者肿瘤坏死因子-α及白细胞介素-6的影响

Effects of massive whole lung lavage on serum TNF-α and IL-6 levels of patients with pneumoconiosis

目的观察大容量肺灌洗术治疗尘肺患者的临床疗效及其对肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)的影响。方法采用肺灌洗治疗尘肺30例,于治疗前及治疗1周后分别行肺功能检查及TNF-α、IL-6检测,并与26例健康者进行比较。结果大容量灌洗后30例尘肺患者肺功能[用力肺活量(FVC)、1秒用力呼气量(FEV1)、最大通气量(MVV)、一氧化碳弥散量(DLCO)]较灌洗前明显改善(P<0.05),两组比较差异均有统计学意义(P<0.05)。30例尘肺患者灌洗前血清TNF-α、IL-6明显高于灌洗后及健康对照组,两组比较差异均有统计学意义(P<0.05)。结论大容量肺灌洗术治疗对尘肺是安全有效的方法,TNF-α、IL-6可以作为判断尘肺患者病情及疗效的指标。

Objective To observe the curative effect of massive whole lung lavage on patients with pneumoconiosis and its effects on tumor necrosis factor-α（TNF-α）and interleukin-6（IL-6）. Methods Thirty patient with pneumoconiosis were trea-ted by massive whole lung lavage,before treatment and after one week’s treatment,the pulmonary function and serum TNF-αand IL-6 levels were detected,and were compared with 26 healthy controls. Results Pulmonary function test（ FVC,FEV1, MVV,DLCO）of 30 pneumoconiosis patients were significantly improved compared with prior treatment（P﹤0. 05 or P﹤0. 01）, The levels of TNF-α and IL-6 of patients with pneumoconiosis before treatment significantly increased compared with those of healthy control group and after treatment（P﹤0. 05 or P﹤0. 01）. Conclusion It is safe and effective to use massive whole lung lavage for the pneumoconiosis. TNF-α and IL-6 can be used as the indexes for judgement of the severity and efficacy of patients with pneumoconiosis.