塞来昔布预防紫杉醇致骨肌肉疼痛的疗效和安全性研究

Effect and safety of celecoxib in the treatment of bone muscle pain caused by paclitaxol

目的探讨塞来昔布预防紫杉醇致骨肌肉疼痛的疗效及安全性。方法选择焦作市第二人民医院2012年1月至2013年9月应用紫杉醇方案化疗的住院患者108例,采用随机法分为试验组和对照组,每组54例。试验组在应用紫杉醇后第2天给予塞来昔布片200 mg,每12小时1次,连用2 d。使用NRS疼痛评分记录两组患者的疼痛情况。记录两组患者不良反应情况,并进行统计分析。结果试验组和对照组疼痛发生率在紫杉醇治疗的第1天和第4、5天比较差异无统计学意义,在第2、3天疼痛发生率差异均有统计学意义(P<0.05)。第2、3天对照组中重度疼痛的发生率明显高于试验组。结论塞来昔布能明显减轻紫杉醇所导致的骨肌肉疼痛,改善患者的生活质量,安全性好,可作为紫杉醇化疗时的常规用药。

Objective To study the efficacy and safety of celecoxib in the treatment of bone muscle pain caused by paclitax-ol. Methods From Jan 2012 to Sep 2013,108 patients received paclitaxel chemotherapy were divided into experimental group and control group,with 54 cases in each group. Patients in experimental group were given celecoxib 200 mg,q12h,on second and third day after the application of paclitaxol. The degree of pain in the two groups were recorded with the NRS and the adverse reactions were recorded and analyzed. Results There was no significant difference in the incidence of pain in the two groups on the first,fourth and fifth day after the application of paclitaxol. There were significant differences in the incidence of pain in the two groups on the second and third day after the application of paclitaxol（P﹤0. 05）. The incidences of moderate and severe pain in the control group were obviously higher than those in experimental group on the second and third day after the application of pa-clitaxol. Conclusion Celecoxib can obviously relieve the bone muscle pain caused by paclitaxel,and improve the quality of life. It is safe and can be used as conventional drugs after chemotherapy with paclitaxel.