乙肝表面抗原在慢性乙型肝炎病毒感染临床不同阶段的变化

Quantitation value of HBsAg in different clinical stages of chronic hepatitis B virus infection

目的探讨慢性乙型肝炎病毒（HBV）感染者不同临床阶段乙肝表面抗原（HBsAg）定量值的变化。方法：收集2012年1月至2013年5月安徽医科大学第二附属医院246例未经抗病毒治疗的HBV感染患者血清，其中慢性HBV携带患者（HBV携带组）4l例，慢性乙型肝炎患者（乙型肝炎组）99例，乙肝肝硬化（肝硬化组）患者70例，原发性肝癌（肝癌组）患者36例。结果：在HBV携带组、乙型肝炎组、肝硬化组及肝癌组中HBsAg定量值的中位数（4分位数间距）分别是135 280．oo（1 788．80。51 820．00）IU／mL，8 218．00（1 644．60～266 700．80）IU／mL。1 280．38（265．70～2 375．00）IU／mL．925．10（135．05-2 381．8）IU／mL。HBsAg与HBVDNA定量水平呈正相关性（L=0．332，P=0．000），HBsAg定量与年龄呈负相关性（L=-0．496，P=0．000）。结论：HBV携带组、乙型肝炎组、肝硬化组及肝癌组中HBsAg定量值HBV DNA逐渐下降．且HBsAg定量值与血清HBV DNA水平呈正相关性。HBsAg定量与年龄呈负相关性。

Objective To investigate the levels of HBsAg and HBV DNA in different clinical stages.Methods Serum samples of 246 patients, without accepting antiviral therapy, from the second affiliated anhuimedical univrsity were collected from 2012.1 to 2013.5. Among the enrolled patients, 41 cases with chronic HBV-carrier （ASC）, 99 cases with chronic hepatitis B patients （CHB）, 70 cases with liver cirrhosis （LC）, and 36 caseswith primary liver cancer （HCC） were included. Results Levels of HBsAg in the group of ASC, CHB, LC, HCCwere 135 280.00 （1 788.80 - 51 820.00） IU/mL, 8 218.00 （1 644.60 - 266 700.80） IU/mL, 1 280.38 （265.70-2 375.00） IU/mL, and 925.10 （ 135.05 - 2 381.8） IU/mL, respectively. Positive correlations were observed betweenHBsAg tire and HBV DNA levels （r = 0.332, P = 0.000）, and negative correlations were doserved between HBsAgleve and age（r = -0.496,P = 0.000）. Conclusions The level of HBsAg in serum decreased progressively from thegroup of ASC to CHB, LC and HCC, the positive correlation between levels of HBsAg and HBV DNA, and thenegative correction between HBsAg level and age were demonstrated.