人血管生成素样蛋白3与糖尿病血管病变和血脂紊乱相关性研究

The correlation study on angiopoietin-like protein 3 and diabetic angiopathies,dyslipidemia

目的:探讨作为与血管新生密切相关的一种分泌性蛋白因子—人血管生成素样蛋白3(Angptl 3)是否与糖尿病患者的血脂紊乱、大血管、微血管病变存在某种关联。方法:选择80例糖尿病患者,测定身体质量指数(BMI)、腰围、血脂、糖化血化蛋白(HbA1c)、尿微量白蛋白(UAlb)、肝肾功能、尿酸、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)等指标,并通过酶联免疫吸附剂测定法(ELISA)测定Angptl 3水平。高分辨率彩超查颈动脉内中膜厚度(IMT),通过眼底镜检查糖尿病视网膜病变,并根据2010年《糖尿病防治指南》分期。结果:在80例糖尿病患者中,Angptl 3水平与颈动脉内中膜厚度呈显著正相关(r=0.607,P<0.01),与HDL-C呈显著负相关(r=-0.36,P<0.05),而与UAlb、眼底病变无相关性(P>0.05)。结论:在糖尿患者中,Angptl3可能通过降低HDL-C的水平而引起大血管病变,同时与糖尿病小血管病变的发生无关。

Todiscussthecorrelationbetweenangiopoietin-likeprotein3（Angptl3）anddyslipidemia,mac-roangiopathy,microangiopathy. Angptl 3 is a secreted protein factors closely related to angiogenesis. Methods：Basic parameters such as body mass index（BMI）,waistline,blood fat,hemoglobin A1c（HbA1c）,microalbuminuria（UAlb）,purine trione,tria-cylglycerol（ TG）,cholesterol total（ TC）,High density lipoprotein cholesterol（ HDL-C）,Low density lipoprotein cholesterol （ LDL-C）of 80 patients with diabetes was obtained. Plasma levels of Angtpl 3 were measured by enzyme-linked immunosor-bent assay（ ELISA）. The carotid intima-media thickness（ IMT）was determined by Color Doppler. Check diabetic retinopa-thy by ophthalmoscopy,and according to 2010 Diabetes Prevention Guide installments. Results：In patients with diabetes,An-gptl 3 levels and the thickness of the internal carotid artery intima showed a significant positive correlation correlation （r=0. 607,P﹤0. 01）,and HDL-C were significantly negatively correlated（r= -0. 36,P﹤0. 05）,and with UAlb,retinop-athy was no correlation（P﹥0. 05）. Conclusion：In diabetic patients,Angtpl 3 reducing the level of HDL-C may be caused by vascular disease,while unrelated to the occurrence of small vessel disease and diabetes.