高同型半胱氨酸血症与急性脑梗死相关性分析

Correlation analysis on the hyperhomocysteinemia and acute cerebral infarction

目的:探讨急性脑梗死与高同型半胱氨酸(Hcy)血症的关系。方法:选取150例合并高血压的急性脑梗死住院患者为观察组,另选取同期门诊就诊的未发生脑梗死的高血压患者150例为对照组。两组患者分别进行空腹Hcy水平的测定,并进行比较。根据入院24 h内Hcy是否升高,将150例脑梗死住院患者分为高Hcy组(88例)和正常Hcy组(62例),两组患者分别于住院时及发病4周时进行神经功能缺损评分(NIHSS评分)。结果:高同型半胱氨酸血症在观察组中占58.7%,对照组中占15.3%(P<0.01);空腹Hcy浓度观察组为(31.26±4.61)μmol/L,对照组为(15.92±3.43)μmol/L,差异有统计学意义(P<0.01)。高Hcy组与正常Hcy组入院时NIHSS评分比较,差异无统计学意义(P>0.05)。两组于发病4周时进行NIHSS评分,高Hcy组评分高于正常Hcy组(P<0.01)。结论:高Hcy血症是脑梗死发生的重要危险因素,高Hcy的脑梗死患者预后较差。积极干预高Hcy血症有助于防止脑梗死的发生或改善脑梗死患者的预后。

Tostudytherelevancebetweenhyperhomocysteinemia（Hcy）andacutecerebralinfarction.Meth-ods：One hundred and fifty inpatients with acute cerebral infarction were selected as the observation group and 150 clinical pa-tients with hypertension contemporaneous were selected as the control group. Patients of the two group all had fasting Hcy test and their results were compared. To divide 150 inpatients with acute cerebral infarction into high Hcy group（88 cases）and normal Hcy group（62 cases）. Neurological deficit scores（NIHSS）of the two group were detected when the patient was admit-ted and four weeks after onset. Results：Hyperhomocysteinemia was 58. 7% in the observation group while 15. 3% in the con-trolgroup . Fasting Hcy of the observation group was（ 3 1 . 2 6 ± 4 . 6 1 ）μmol/ L . while that of the control group was（ 1 5 . 9 2 ± 3. 43）μmol/L（P﹤0. 01）. NIHSS had no statistical significance when patients were admitted（P﹥0. 05）. But four weeks af-ter onset,NIHSS of the high Hcy group was higher than the control group（P﹤0. 01）. Conclusion：Hyperhomocysteinemia is important risk factor of acute cerebral Infarction. The patients with acute cerebral Infarction show the poor prognosis while they have higher Hcy. Active intervention to hyperhomocysteinemia will help to prevent acute cerebral Infarction or improve progno-sis of patients with acute cerebral Infarction.