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S100A8/A9在心血管疾病中的作用 被引量:3

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摘要 S100A8/A9是由S100A8与S100A9两种蛋白以共价键联合形成的异二聚体,又叫钙卫蛋白,属于钙结合蛋白家族中最大的亚族S100家族之中的成员,参与了许多生理活动和病理过程,在许多炎症及自身免疫反应中发挥作用。最近大量研究发现S100A8/A9在人和老鼠的心血管疾病中具有重大意义,可能成为反映心血管事件的标志物。本文就S100A8/A9在心血管系统的动脉粥样硬化、急性冠状动脉综合征以及心功能不全等疾病中的作用做一综述。
出处 《社区医学杂志》 2014年第15期11-14,共4页 Journal Of Community Medicine
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  • 1Moore B.A soluble Protein characteristic of the nervous system[J].Biochem BioPhys Res Commun,1965:19:739-744.
  • 2Marenholz L,Hekmann CW,Fritz G.S100 proteins in mouse and man:from Evolution to function and Pathology(including an update of the nomenclature)[J].Bioehem Biophys Res Commun,2004,322(4):1111-1122.
  • 3Rammes A,Roth J,Goebeler M,et al.Myeloid-related protein MRP8 and MRP14,calcium-binding proteins of the S100 family,are secreted by activated monocytes via a novel,tubulin-dependent pathway[J].J Biol Chem,1997,272:9496-9502.
  • 4Eggers K,Sikora K,Lorenz M,et al.RAGE-dependent regulation of calcium-binding proteins S100A8 and S100A9 in human THP-1[J].Exp Clin Endocrinol Diabetes,2011,119:353-357.
  • 5Lim SY,Raftery MJ,Geczy CL.Oxidative modifications of DAMPs suppress inflammation:The CASe for S100A8 and S100A9[J].Antioxid Redox Signal,2011,15(8):2235-2248.
  • 6Croce K.S100A8/A9 complex:more than just a biomarker of cardiovAScular risk?[J].Circ J,2010,74:626-627.
  • 7Goyette J,Geczy CL.Inflammation-ASsociated S100 proteins:new mechanisms that regulate function[J].Amino Acids,2011,41:821-842.
  • 8Kerkhoff C,Klempt M,Kaever V,et al.The two calcium-binding proteins S100A8 and S100A9 are involved in the metabolism of arachidonic acid in human neutrophils[J].J Biol Chem,1999,274:32672-32679.
  • 9Vogl T,Ludwig S,Goebeler M,et al.MRP8 and MRP14 control microtubule reorganization during transendothelial migration of phagocytes[J].Blood,2004,104:4260-4268.
  • 10Vogl T,Tenbrock K,Ludwig S,et al.Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4,promoting lethal,endotoxin-induced shock[J].Nat Med,2007,13:1042-1049.

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