含铜不锈钢材料对冠状动脉支架植入后再狭窄的抑制作用探讨

The Discussion of Copper Stainless Steel for the Inhibition of Restenosis after Coronary Stent Implantation

经皮冠状动脉内支架植入术已经成为冠心病的主要有效治疗方法之一,然而再狭窄的发生仍然是术后的主要隐患,支架异物及其对血管壁的机械损伤不可避免地成为了再狭窄的始动因素,随后激活血小板及一系列炎症细胞,炎症细胞及内皮细胞释放多种炎症介质,从而激活过度的炎症反应,最终导致血管平滑肌细胞的迁移和增殖、细胞外基质的堆积、新生内膜形成、血管重构,引起再狭窄。炎症反应作为再狭窄的中心环节一直是我们破解再狭窄的切入点,而含铜不锈钢材料在多种试验中证实具有抗菌、促进内皮细胞增殖及早期凋亡的特性。本研究就再狭窄与中心环节的炎症反应和铜材料的抑制过度炎症反应作用做一探讨。

Percutaneous coronary stent implantation has become one of the main effective methods of coronary heart disease , however ,restenosis remains a major risk of postoperative stent foreign objects and mechanical damage to the vessel wall inevitably become a restenosis initiating factor , platelet activation and subsequent series of inflammatory cells , inflammatory cells and endothelial cells release a variety of inflammatory mediators , thereby activating the excessive inflammatory response , resulting in the accumulation of vascular smooth muscle cell migration and proliferation , extracellular matrix ,neointimal formation ,vascular remodeling ,causing restenosis .Inflammation as a central part of restenosis has been our starting point to crack restenosis ,while copper has antibacterial stainless steel confirmed in a variety of tests ,to promote appreciation and early apoptotic endothelial cells .The study on restenosis and inflammation and suppress the central link of the copper material over the role of inflammation does a discussion .