摘要
目的:评价全天麻咀嚼胶的体外释放情况。方法以人工唾液为介质,采用高效液相色谱法测定全天麻咀嚼胶中天麻素的质量分数,采用咀嚼释放度测定仪(自制)检测咀嚼胶体外释放度,检测波长为220 nm,介质体积为40 mL。结果天麻素在0.042-0.378μg范围内线性良好,平均回收率为99.18%, RSD为2.40%;全天麻咀嚼胶在8 min左右,天麻素释放达90.0%以上。结论全天麻咀嚼胶中天麻素释放迅速,可作为一种新型的降血压及治疗头痛的中药制剂进一步开发。
Objective To evaluate the in vitro dissolution of gastrodine chewing gum. Method The content of gastrodine in Gastrodia elata chewing gum was determined by HPLC and the dissolution of gastrodine was studied with a specialized release-measuring apparatus made-self in 40 mL artificial saliva at the detection wavelength of 420 nm. Result The linear range of gastrodine was from 0. 042 to 0. 378 μg and the average recovery was 99.18% with a RSD of 2.40%.Approximately 90.0% of the gastrodine contained in Gastrodia elata chewing gums was released in about 8 min. Conclusion Gastrodia elata chewing gum is a fast-released preparations and suitable for lowering blood pressure and treating headaches.
出处
《广东药学院学报》
CAS
2014年第4期404-407,共4页
Academic Journal of Guangdong College of Pharmacy
基金
中央高校基本科研业务费专项资金资助项目(2682013CX035)
关键词
天麻咀嚼胶
释放度
天麻素
释放度测定仪
Gastrodia elata chewing gum
release
gastrodine
release-measuring apparatus