神经妥乐平联合甲基泼尼松龙治疗急性脊髓损伤的临床研究

Clinical research on the effect of neurotropin combined with methylprednisolone in the treatment of acute spinal cord injury

【目的】评价神经妥乐平联合甲基泼尼松龙在治疗急性脊髓损伤中的应用价值。【方法】将71例急性脊髓损伤患者随机分为两组,治疗组采用神经妥乐平联合甲基泼尼松龙治疗,对照组采用甲基泼尼松龙治疗,并对比两组病例神经功能改善情况。【结果】两组病例均获随访,时间10~24个月,平均12个月。治疗组神经功能改善的有效率为88.46%,优于对照组的68.0%,两者差异具有统计学意义（P〈0.05）。【结论】神经妥乐平联合甲基泼尼松龙治疗急性脊髓损伤,比单独应用甲基泼尼松龙治疗脊髓损伤有更好的临床效果。

[ Objective ] To research the effect of neurotropin combined with methylprednisolone in the treatment of acute spinal cord injury. [Methods] A total of 71 patients diagnosed as acute spinal cord injury were randomly divided into treatment group and control grnup. The treatment group was given neurotropin combined with methylprednisolone, and the control group was given methylprednisolone. Neurological function of two groups were observed after treatment. [ Results ] 71 eases were followed up from 10-24 months （average 12 months）. After treatment, the effect of neurological function were significantly different between treatment group （88.46%） and control group （68.0%）. [ Conclusion ] The use of neurotropin combined with methylprednisolone in treating acute spinal cord injury can promote axon formation, Sehwann cell proliferation, the recovery of the nerve injury, so it is worth clinical use.