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钙调蛋白S100A8/A9在结直肠癌肝转移患者中的表达意义 被引量：1

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摘要 目的：探讨结直肠癌肝转移患者原位灶钙调蛋白S100A8/A9的表达情况,以及与肝转移数之间的关联性.方法：搜集我院2005年4月～2013年10月间的结直肠癌肝转移患者临床病理资料及结直肠癌原发灶标本,采用免疫组织化学分别检测S100A8/A9在正常结直肠黏膜组织及原发灶中的表达水平,利用卡方检验方法分析肝转移数与S100A8/A9之间的相关性.结果：S100A8及S100A9分别在正常粘膜组与原发灶组对比中,原发灶组S100A8与S100A9含量均比正常粘膜组含量明显增高,差异均具有统计学意义（均P＜0.0001）.原发灶S100A8与S100A9含量分别与肝转移数行卡方检验,结果显示S100A8与S100A9水平均与肝转移数相关,差异均具有统计学意义（P＜0.05）.结论：结直肠癌肝转移患者中,原发灶S100A8/A9含量明显升高,并随着S100A8/A9表达的升高,肝转移数量增多的风险随之增加.
作者 梁玉梅 孙振强
机构地区 新疆生产建设兵团第二师库尔勒医院骨二科 新疆医科大学附属肿瘤医院胃肠外科
出处 《新疆医学》 2014年第5期33-35,共3页 Xinjiang Medical Journal
基金 新疆医科大学科研创新基金(XJC201267)
关键词 S100A8 S100A9 结直肠癌 肝转移 相关性
分类号 R735.35 [医药卫生—肿瘤]
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参考文献15

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新疆医学
2014年 第5期

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