沙棘对功能性消化不良患儿神经肽Y、胃动力及体脂的影响

Influence of hippophae rhamnoides on neuropeptide Y, gastric emptying and body fat in children with functional dyspepsia

目的：探讨沙棘对功能性消化不良（ FD）患儿食欲因子神经肽Y（ NPY）水平及其胃动力、体脂的影响。方法选择符合FD诊断标准的患儿120例，采用单纯随机抽样方法分为三组，Ⅰ组单纯予以沙棘干乳剂治疗，Ⅱ组予以多潘立酮治疗，Ⅲ组予以沙棘干乳剂加多潘立酮治疗，共8周，治疗前后分别测血浆NPY水平，并采用B超检查作胃液体排空试验测餐后30 min、60 min、90 min和120 min的胃窦残留率，测量患儿皮下脂肪平均值、体脂比、上臂围、体质量、身高。结果Ⅰ组、Ⅱ组、Ⅲ组血浆食欲因子NPY水平治疗前分别是（107．52±24．12）ng/L、（114．63±17．95）ng/L和（114．56±25．10）ng/L，差异无统计学意义（F＝1．307， P＞0.05）；经治疗后，三组血浆NPY分别是（137．38±29．86） ng/L、（121．43±13．78） ng/L和（149．27±31．9） ng/L，差异有统计学意义（F＝11．23，P＜0．05）；Ⅰ组、Ⅲ组NPY水平治疗后明显高于治疗前（t＝4．95、5．40，均P＜0．05）。Ⅰ组、Ⅲ组餐后60 min、90 min和120 min的胃窦残留率比Ⅱ组同期均明显减少（ F＝4．93、6．40、4.61，P＜0．05）；Ⅰ组、Ⅲ组皮下脂肪平均值﹑体脂比、上臂围、体质量增加值显著高于Ⅱ组（ F＝16．80、46.9、21．06、12．08，均P＜0．05）。而Ⅰ组与Ⅲ组两组治疗后食欲因子NPY水平、胃窦残留率及皮下脂肪平均值﹑体脂比、上臂围、体质量比较，差异均无统计学意义（均P＜0．05）。结论沙棘对FD患儿食欲因子NPY有明显调节作用，促进胃排空，同时患儿体脂明显增加，体格发育明显改善。

Objective To explore the effect of hippophae rhamnoides on the level of plasma appetite factors neuropeptide Y ,the gastric motility and on their body fat in children with functional dyspepsia .Methods A hundred and twenty children with functional dyspepsia were simple random sampled divided into the three groups ：Group Ⅰ（ treated with hippophae rhamnoides ） ,Group Ⅱ（ treated with domperidone ） , and Group Ⅲ（ treated with hippophae rhamnoides plus domperidone ） .The treatment lasted for eight weeks .The level of plasma neuropeptide Y （ NPY） were measured before and after treatment .All patients underwent a gastric emptying （ GE） test by ultrasound （ US） to measure the rate of postprandial gastric antrum residual ,at 30min,60min,90min and 120min.The average value of subcutaneous fat,body fat percentage,upper arm girth,weight and height were also measured .Results There were no statistical difference between the level of NPY in plasma of groupⅠ,ⅡandⅢbefore treatment,which were （107.52 ±24.12）ng/L, （114.63 ±17.95）ng/L and（114.56 ±25.10）ng/L（F=1.307,P〉0.05）.After treatment,there were statistical difference between the level of NPY in plasma of groupⅠ,ⅡandⅢ,which were （137.38 ±29.86） ng/L,（121.43 ± 13.78）ng/L and （149.27 ±31.9）ng/L.The level of NPY in plasma of groupⅠandⅢwere markedly increased after treatment（t=4.95,5.40,all P〈0.05）.The postprandial gastric antrum remains in Groups ⅠandⅢwere less than that in group Ⅱat 60 min,90 min and 120 min,respectively（F=4.93,6.40,4.61,all P〈0.05）.The thickness of skin fold（SF）,body fat percentage and upper arm girth and weight in groupⅠand Ⅲ increased more than those in group Ⅱ（F=16.80,46.9,21.06,all P〈0.05）.The level of plasma appetite factors ,the rate of gastric antrum remaing and SF,body fat percentage,arm girth and weight was similar in groupⅠand group Ⅲ （P 〉0.05）. Conclusion In children′s functional dyspepsia ,the hippophae rhamnoides increases the level of appetite factor neu-ropeptide Y,The child′s body fat increases markedly and physical growth also has obvious improvement .