摘要
目的:探讨婴儿接种乙型肝炎疫苗的免疫效果及低、无应答者再免疫效果。方法筛查松滋市妇幼保健院2000例7~12个月婴儿乙型肝炎疫苗初次免疫(初免)的效果,分析影响初免的因素,对初免低或无应答婴儿选择10μg汉逊酵母乙型肝炎疫苗或5μg重组酵母乙型肝炎疫苗进行再次接种(再免),分析再免1、3次后的效果。结果(1)2000例婴儿乙型肝炎疫苗初免应答率为92.2%,平均抗-HBs几何抗体浓度(GMC)为:(321.88±100.45)IU/L,其中父母HBsAg阳性和在乡镇医院出生的婴儿应答率较低,与父母HBsAg阴性和在县级以上医院出生的婴儿差异均有统计学意义(χ2=30.61、47.58,均P<0.05)。(2)两种疫苗再免1次、3次GMC含量均比再免前增高,差异均有统计学意义(t=98.32、102.15,均P<0.05);再免3次较再免1次应答率及GMC含量高,差异均有统计学意义(t=98.55、102.33,均P<0.05);汉逊酵母乙肝疫苗再免1次、3次后GMC含量较高,与重组酵母乙型肝炎疫苗差异均有统计学意义( t=104.11、124.31,均P<0.05)。结论父母HBsAg阳性和在基层医院出生的婴儿低、无应答比例较高,再免后应答率较高,汉逊酵母乙型肝炎疫苗效果较好。
Objective To investigate the immune effect of neonatal hepatitis B vaccination and its once more immune effect in low or no responders .Methods Screening Songzi city MCH 2 000 cases of hepatitis B vaccine 7-12 months baby's first immunization effect ,analyze the impact of the prime factors for early response in children with low or no free choice 10μg Hansenula yeast recombinant hepatitis B vaccine or 5μg hepatitis B vaccine ( HepB-SC) , carried revaccination(Immune again),then analyzed the effect of free 1,3 times.Results (1) Primary immune response rate of neonatal hepatitis B vaccine in 2 000 cases was 92.2%,the average anti-HBsGMC was (321.88 ± 100.45) IU/L,in which the HBsAg positive persons and birth in the township hospital neonatal response rate was low that had a statistically significant (χ2 =30.61,47.58,all P 〈0.05) difference with the children whose parents'HBsAg was negative and borned in hospitals above the county level;( 2 ) GMC content was increase in once more immune at 1,3 times than before,the difference was statistically significant (t=98.32,102.15,all P〈0.05),and the 3 time is higher than the 1 time once more immuneof levels of GMC ,the difference was statistically significant ( t=98.55,102.33,all P〈0.05),content of GMC is higher in once more immune of Hansenula hepatitis B vaccine at 1, 3 times when compared with the recombinant hepatitis B vaccine , the difference was statistically significant ( t =104.11,124.31,all P〈0.05).Conclusion Low and non-responders'proportion is high in the children whose par-ents'HBsAg is positive and be born in the primary hospital ,which has a higher response rate after once more immune , Hansenula hepatitis B vaccine has a better immune effect .
出处
《中国基层医药》
CAS
2014年第17期2593-2595,共3页
Chinese Journal of Primary Medicine and Pharmacy
关键词
肝炎疫苗
乙型
免疫
新生儿筛查
Hepatitis B vaccines
Immunity
Neonatal screening