甘草及其活性成分对生殖系统药理作用研究进展

Advances in pharmacologic studies on Glycyrrhizae Radix and its active components in genital system

甘草及其活性成分对实验动物生殖系统有影响,甘草酸及其甘草黄酮类化合物是甘草呈现该药理作用的活性成分。甘草酸通过抑制睾酮生物合成和促进睾酮代谢,降低血睾酮水平,还能抗生殖器官炎症和肿瘤;但其又能抑制磺基转移酶2A1活性和提高5α-甾体还原酶活性,导致临床上应用甘草和甘草酸不一定会产生血睾酮水平下降。甘草黄酮类化合物属植物雌激素,在机体缺乏雌激素时表现出雌激素样作用;当机体雌激素水平过高时表现为拮抗雌激素作用,是甘草治疗痛经和生殖器官肿瘤的主要活性成分。

To study the effect of glycyrrhizinic acid and licorice flavonoids on the genital system in animal, which are the active components from Glycyrrhizae Radix with the genital pharmacologic effects on anti-inflammation and antitumor in genital organs. Glycyrrhizinic acid could reduce serum testosterone level by inhibiting the biosynthesis and promoting the metabolism of testosterone, and has the effect of anti-inflammation and antitumor in genital organs. The effect of glycyrrhizinic acid on decreasing SULT2A1 activity while increasing steroid-5a-reductase activity, induces Glycyrrhizae Radix and glycyyrhizinic acid to be no sure to exhibit the reduction of serum testosterone level in clinic. Licorice flavonoids belong to phyto-estrogen. When the body is short of estrogen, licorice flavonoids exhibit estrogen-like effects. When the body is overfull of estrogen, licorice flavonoids exhibit antagonism to estrogen. Licorice flavonoids are major active components of Glycyrrhizae Radix for the treatments of genital organs carcinoma and dysmenorrheal.