摘要
目的对宽叶兔儿风Ainsliaea latifolia全草的化学成分进行研究。方法采用硅胶柱色谱、凝胶柱色谱、中压制备液相、高压制备液相等方法进行分离纯化,通过核磁共振、质谱等波谱手段对化合物进行结构鉴定。结果从宽叶兔儿风80%乙醇提取物中分离得到13个化合物,分别鉴定为木栓酮(1)、蒲公英萜醇乙酸酯(2)、3β-hydroxy-11α,12α-epoxyfriedoolean-14-ene(3)、careborin(4)、cis-careborin(5)、3α-E-feruloyltaraxerol(6)、3α-Z-feruloyltaraxerol(7)、3-oxo-11α-methoxyolean-12-ene(8)、diaspanolide A(9)、diaspanolide B(10)、ainsliaolide A(11)、豆甾醇(12)、β-谷甾醇(13)。结论13个化合物中包括8个三萜类化合物(1~8),3个倍半萜类化合物(9-11),2个甾体类化合物(12-13)。化合物1-13均为首次从该植物中分离得到。
Objective To isolate and identify the chemical constituents of Ainsliaea latifolia. Methods Compounds were isolated by various kinds of column chromatographies on silica gel, Sephadex LH-20, MPLC, and HPLC, and their structures were elucidated by the physicochemical properties and spectral analyses. Results Thirteen chemical constituents were obtained and identified as friedelin(1), taraxeryl acetate(2), 3β-hydroxy-11α, 12α-epoxy-friedoolean-14-ene(3), careborin(4), cis-careborin(5), 3α-E-feruloyltaraxerol(6), 3α-Z-feruloyltaraxerol(7), 3-oxo-11α-methoxyolean-12-ene(8), diaspanolide A(9), diaspanolide B(10), ainsliaolide A(11), stigmasterol(12), and β-sitosterol(13). Conclusion Among the isolated 13 compounds, there are 8 triterpenoids(1—8), 3 sesquiterpenoids(9—11), and 2 steroidals(12—13). All the compounds are isolated from A. latifolia for the first time.
出处
《中草药》
CAS
CSCD
北大核心
2014年第15期2148-2152,共5页
Chinese Traditional and Herbal Drugs
关键词
宽叶兔儿风
菊科
木栓酮
蒲公英萜醇乙酸酯
豆甾醇
Β-谷甾醇
Ainsliaea latifolia(D.Don) Sch.-Bip.
Compositae
friedelin
taraxeryl acetate
stigmasterol
β-sitosterol