毛郁金的化学成分研究

Chemical constituents in roots and rhizomes of Curacuma aromatica

目的研究毛郁金Curacuma aromatica根茎的化学成分。方法采用硅胶柱色谱、Sephadex LH-20、制备液相等多种手段进行分离纯化,根据理化性质和波谱数据鉴定化合物的结构。结果从毛郁金95%乙醇提取物中分离得到17个化合物,分别鉴定为莪术二酮(1)、β-谷甾醇(2)、豆甾醇(3)、三十烷酸(4)、桂莪术内酯(5)、莪术烯醇(6)、原莪术烯醇(7)、eudesmane-3,6-dione(8)、羽扇豆醇(9)、姜黄素(10)、去甲氧基姜黄素(11)、aerugidiol(12)、蓬莪二醇(13)、voleneol(14)、尿嘧啶(15)、莪术醇(16)、莪术双环烯酮(17)。结论化合物4、5、8、9、14和15均为首次从该植物中分离得到。

Objective To investigate the chemical constituents in the roots and rhizomes of Curacuma aromtica. Methods The chemical constituents were separated and purified by silica gel, Sephadex LH-20 column chromatography, preparative HPLC, and so on. Their structures were determined by physicochemical constants and spectral analyses. Results Seventeen compounds were obtained and identified as curdione （1）, β-sitosterol （2）, stigmasterol （3）, triaconatanoic acid （4）, gweicurculactone （5）, curcumenol （6）, procurcumenol （7）, eudesmane-3, 6-dione （8）, lupeol （9）, curcumin （10）, demethoxycurcumin （11）, aerugidiol （12）, zedoarondiol （13）, voleneol （14）, uracil （15）, curcumol （16）, and curcumenone （17）. Conclusion Compounds 4, 5, 8, 9, 14, and 15 are isolated from the plant for the first time.