α-硫辛酸、舒血宁联合甲钴胺治疗糖尿病周围神经病变的临床观察

Clinical observation of α-lipoic acid and shuxuening combined with mecobalamin in treatment of diabetic peripheral neuropathy

目的：观察α-硫辛酸、舒血宁联合甲钴胺治疗糖尿病周围神经病变（ DPN）的临床疗效。方法将70例DPN患者随机分为两组，观察组采用α-硫辛酸＋舒血宁＋甲钴胺治疗，对照组采用甲钴胺治疗。观察两组的临床疗效、神经传导速度、多伦多临床评分系统（ TCSS）的评分与血浆超敏C-反应蛋白（ hs-CRP）水平在治疗前后的变化。结果观察组总有效率为91.43%，高于对照组的71.43%，差异有统计学意义（ P﹤0.05）；治疗后两组TCSS评分、血浆hs-CRP水平均明显降低，神经传导速度（ NCV）均增加，上述指标改善情况观察组优于对照组，差异有统计学意义（ P﹤0.05）。结论α-硫辛酸、舒血宁联合甲钴胺治疗糖尿病周围神经病变疗效确切。

Objective To observe the clinical efficacy ofα-lipoic acid and shuxuening combined with mecobalamin on diabetic peripheral neuropathy（ DPN）. Methods Seventy patients with DPN were randomly divided into two groups（ observation group and control group）,observation group was given α-lipoic acid,shuxuening and mecobalamin,control group was given mecobalamin. The clinical efficacy, the improving condition of NCV,the TCSS score and the peripheral blood level of hs-CRP before and af-ter treatment was observed. Results The efficacy of observation group（91. 43%）was higher than that of control group（71. 43%）,there was significant difference（P﹤0. 05）. The TCSS score,the levels of hs-CRP were significantly reduced（ P ﹤0. 05 ）,and the NCV obviously increased（ P ﹤0. 05 ）in both group after treatment,and there were significant differences between the two groups after treatment（ P﹤0. 05）. Conclusions α-lipoic acid,shuxuening combining with mecobalamin is effective on diabetic peripheral neuropathy.