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线粒体电压依赖性阴离子通道1在阿尔茨海默病发生机制中的作用 被引量：3

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摘要 线粒体电压依赖性阴离子通道(voltage-dependent anion channel,VDAC)是存在于线粒体外膜上的一系列孔道蛋白,其亚型之一VDAC1参与线粒体通透性转换(MPT)孔道的功能发挥,调控阳离子、阴离子、ATP、无机磷酸盐以及其他代谢产物进出线粒体。研究发现,随着阿尔茨海默病(AD)的发生发展,VDAC1蛋白表达水平提高,且其与β-淀粉样蛋白(Aβ)及磷酸化tau蛋白相互作用,干扰ATP/ADP、蛋白质等代谢产物的转运。现就VDAC1的结构、特性以及在AD发病中的机制作一综述。
作者 奚用勇 蒋与刚 卢豪
机构地区 军事医学科学院卫生学环境医学研究所 武汉大学 天津医科大学 成都军区疾病预防控制中心
出处 《生理科学进展》 CAS CSCD 北大核心 2014年第4期318-320,F0003,共4页 Progress in Physiological Sciences
基金 2013年度全军医学科技青年培育项目(13QNP069) 天津市应用基础与前沿技术研究计划重点项目(14JCZDJC36100)资助课题
关键词 线粒体电压依赖性阴离子通道1 阿尔茨海默病 Β-淀粉样蛋白 磷酸化TAU蛋白
分类号 R363 [医药卫生—病理学]
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参考文献11

  • 1Heddy PH. Is the mitochondrial outerrmembrane protein VDACI therapeutic target for Alzheimer s disease. Biochimica Biophysica Acta, 2013,1832: 67 -75.
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二级参考文献15

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生理科学进展
2014年 第4期

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