阿加曲班对急性脑梗死患者神经功能缺损程度及凝血功能的影响

The Influence of Argatroban on the Nerve Function Defect and Blood Coagulation in Patients with Acute Cerebral Infarction

目的:探讨阿加曲班应用于急性脑梗死中对患者神经功能缺损程度及凝血功能的影响。方法:选择2011年10月-2013年10月在本院进行治疗的急性脑梗死患者98例,采用随机数字表法将其分为观察组和对照组,每组各49例,其中对照组给予常规治疗,观察组则给予阿加曲班静脉滴注治疗,疗程为2周,治疗结束后对两组患者的神经功能缺损程度(CSS)进行评分,并对患者的凝血常规等指标变化进行观察和分析。结果:观察组的治疗效果明显高于对照组,临床神经功能缺损程度(CSS)评分也明显优于对照组,且两组比较差异均有统计学意义(P<0.05);观察组经治疗后凝血酶原时间复查也基本恢复正常,未见明显不良反应和过敏反应。结论:阿加曲班能有效恢复急性脑梗死患者神经功能缺损和凝血功能,在治疗急性脑梗死方面安全、有效。

Objective：To investigate the influence of argatroban on the nerve function defect and blood coagulation in patients with acute cerebral infarction. Method：98 patients with acute cerebral infarction in our hospital from October 2011 to October 2013 were selected and divided into the observation group and the control group according by random digit table,the control group（49 cases）was given conventional treatment,the observation group（49 cases）were treated with argatroban infusion therapy,treatment duration was 2 weeks. The neurological impairment（CSS score）in the two group was evaluated after the treatment,and the changes of coagulation index were also analyzed. Result：The treatment effect and clinical nerve function damage degree（CSS）scores in the observation group were superior to the control group （P〈0.05）. After treatment,the prothrombin time review returned to normal in the observation group. No obvious adverse reaction and allergic reaction were seen. Conclusion：Argatroban can effectively restore the defect of neural function and coagulation function in patients,it is safety and efficacy in acute cerebral infarction patients.