摘要
目的:观察两种质子泵抑制剂(PPI)治疗内镜下止血后再出血的胃十二指肠溃疡的效果。方法:将2010年5月-2012年7月118例在本院住院的符合入选标准的胃十二指肠溃疡出血胃镜下止血后再出血的患者,按入院先后次序半随机分成试验组和对照组各59例,试验组与对照组分别采用大剂量口服雷贝拉唑、奥美拉唑静脉恒速泵入治疗,治疗72 h后稳定的患者,第4天两组患者再继续10 mg/d雷贝拉唑口服,至第6周胃镜检查,判断治疗效果。结果:两组患者6周内失访人数试验组3例(5.08%),对照组6例(10.17%)(P>0.05)。两组患者治疗后试验组再出血率为1.79%、手术1.79%,对照组再出血率为5.66%、手术3.77%、输血1.89%(P>0.05)。结论:大剂量口服雷贝拉唑与奥美拉唑静脉恒速泵入治疗内镜下止血后再出血的胃十二指肠溃疡均有比较好的疗效,但大剂量口服雷贝拉唑治疗安全、费用相对低、患者能接受,值得临床推广应用。
Objective：To observe effects of large doses of oral rabeprazole and omeprazole intravenous constant speed pump（proton pump inhibitors PPI ）in treatment of rebleeding after endoscopic hemostasis in patients with gastric ulce. Method：118 patients with gastroduodenal ulcer rebleeding after endoscopic hemostasis（met the inclusion criteria ） from May 2010 to July 2012 in our hospital were semi-randomly divided into experimental group and control group,each of 59 cases,the experimental and control groups were treated by large doses of oral rabeprazole,omeprazole intravenous constant speed infusion,respectively.The stable patients in 72 h after treatment were treated by continue 10 mg/d of oral rabeprazole for two groups in first four days. Therapeutic effect was determined by gastroscopy after six weeks.Result：3 patients（5.08%）in experimental group,and 6 patients（10.17%）in the control group were losted within 6 weeks（P〉0.05）. After treatment,rebleeding rate was 1.79%,1.79%surgical in the experimental group.Rebleeding rate was 5.66%,3.77%surgery,blood transfusion 1.89%in the control group（P〉0.05）.Conclusion：Patients with rebleeding gastric ulcer after endoscopic hemostasis are treated by high dose oral rabeprazole,omeprazole intravenous constant speed infusion have better efficacy,but large doses of oral rabeprazole is safety,the cost is relatively low,the patient can accept for patients with rebleeding gastric ulcer after endoscopic hemostasis.The method is worthy of clinical application.
出处
《中国医学创新》
CAS
2014年第24期138-141,共4页
Medical Innovation of China
