摘要
目的:观察以益气养血、滋阴明目为组方原则的芪明颗粒联合羟苯磺酸钙胶囊治疗糖尿病视网膜病变非增殖期患者的疗效。方法:选择2012年6月-2013年2月门诊非增殖期糖尿病视网膜病变患者86例,按随机对照的原则分为两组,各43例。试验组给予芪明颗粒联合羟苯磺酸钙胶囊治疗,对照组给予羟苯磺酸钙胶囊治疗。观察两组患者治疗前后视力及视网膜的变化。结果:治疗后,试验组视力恢复程度、眼底情况均优于对照组,差异均有统计学意义(P<0.05);试验组总有效率为90.7%,对照组为69.8%,试验组优于对照组,差异有统计学意义(Z=-2.204,P=0.028);两组的空腹血糖、糖化血红蛋白比较差异均无统计学意义(P>0.05),且治疗过程中均未发现不良反应。结论:芪明颗粒联合羟苯磺酸钙胶囊治疗对促进非增殖期糖尿病视网膜病变患者视力提高、眼底出血、渗出的吸收比单纯羟苯磺酸钙胶囊治疗更有效;其在疾病疗效、主要症状体征、实验室指标及安全级别方面,优于单纯应用羟苯磺酸钙胶囊,值得在临床广泛应用。
Objective: To observe curative effect of reinforcing Qi and nourish blood,nourishing Yin and eyesight prescription principles of Qiming granule combined with calcium dobesilate capsules in the treatment of patients with nonproliferative diabetic retinopathy.Method:86 cases of nonproliferative diabetic retinopathy were selected from June 2012 to February 2013,and they were divided into two groups according to the principle of randomized,controlled,each group had 43 cases.The experimental group was given the Qiming granule combined with calcium dobesilate capsules, the control group was given calcium dobesilate capsules. Before and after treatment,vision and the change of retina of the two groups were observed.Result:After treatment,patients degree of visual acuity and fundus in the experimental group were superior to the control group,the differences had statistical significance(P〈0.05);the total effective rate of the experimental group was 90.7%,the control group was 69.8%,the experimental group was better than that of the control group,the difference was statistically significant(Z=-2.204,P=0.028). The fasting glucose,glycosylated hemoglobin of two groups were compared,the differences had no statistical significance(P〉0.05),and in the treatment period,there were no adverse reactions.Conclusion:The Qiming granule combined with calcium dobesilate capsules in the treatment of patients with nonproliferative diabetic retinopathy,can promote visual acuity,fundus hemorrhage,exudation,and more effective than pure calcium dobesilate capsules treatment. In diseases,main symptoms and signs,laboratory index and the security level,it is better than the application of calcium dobesilate capsules,worthy of clinical promotion.
出处
《中国医学创新》
CAS
2014年第20期99-102,共4页
Medical Innovation of China