中西医不同疗法治疗生殖道炎症相关的抗精子免疫性不孕的效果分析

The Effectiveness Analysis on Different TCM Therapy for Genital Tract Inflammation Associated with Anti-sperm Immune Infertility

目的:探讨生殖道炎症与抗精子免疫性不孕的相关性及比较分析中西医不同疗法治疗抗精子免疫性不孕的疗效。方法:从2011年1月-2013年12月本院收治的320名不孕患者中筛选出合格受试者88例,30例采用西药治疗;28例分为阴虚血瘀组、30例湿热蕴积组,分别采用不同中药方剂治疗。结果:320例不孕患者中,合并生殖道炎症者88例,AsAb阳性率54.55%;非炎症者232例,AsAb阳性率29.74%,合并生殖道炎症与非炎症者比较有统计学差异(P<0.05)。3种不同疗法对不孕患者均有显著疗效,三组之间的总有效率差异无统计学意义(P>0.05)。中西医疗法均能在显著降低宫颈黏液IL-2表达量、UU、CT阳性率的同时,显著降低血清抗精子抗体的表达(P<0.05)。结论:中西医疗法均能降低炎症指标水平,起到清除或抑制AsAb产生的作用,从而达到有效治疗炎症性抗精子免疫性不孕的效果。

Objective： To investigate correlation of the reproductive tract inflammation and anti-sperm immune infertility,efficacy of comparative different TCM therapy for anti-sperm immune infertility. Method：88 patients with infertile were screened in 300 cases from January 2012 to December 2013 in our hospital,30 cases were treated by western medicine;28 cases in yin and blood stasis group,30 cases in heat simmers groups were respectively applicated different prescription medicine treatment. Result：AsAb positive rate in 88 cases with genital tract inflammation and 232,with non-inflammatory were Respectively 54.55%;and 29.74%from 320 patients,with infertility,which were significantly different （P〈0.05）.Three kinds of different treatments had a significant effect on infertility patients,there was no significant difference in efficiency（P〉0.05）between the three groups. TCM therapy could significantly reduce cervical mucus expression of IL-2,UU,CT-positive rate,while significantly reducing the expression of anti-sperm antibodies in serum （P〈0.05）. Conclusion：TCM therapy can reduce the level of inflammatory markers,remove or inhibit AsAb produced, so as to achieve effects of treating in anti-sperm immune infertility with flammatory.