异丙酚联合异氟醚对下腹部手术围术期麻醉应激反应的影响分析

Analysis of the Effects of Propofol and Isoflurane Anesthesia on Stress Reaction in Perioperative Period of Abdominal Operation

目的:探讨异氟醚与异丙酚对下腹部手术围术期麻醉应激反应的影响分析。方法:选取本院需进行下腹部手术患者140例,按随机数字表法均分为异氟醚组和异丙酚组。分别进行异氟醚吸入维持麻醉以及异丙酚微泵维持麻醉,观察两组患者各项指标并进行对比。结果:两组麻醉后血糖以及皮质醇浓度均有升高,异氟醚组升高尤其明显(P<0.05);在MAP、HR方面,异丙酚组麻醉前后比较差异均无统计学意义(P>0.05),而异氟醚组在麻醉后10 min出现较明显降低(P<0.05);麻醉后,异氟醚组的血浆黏度、红细胞聚集指标、全血高切黏度与麻醉前比较均明显降低(P<0.05),而异丙酚组仅全血高切黏度降低(P<0.05)。结论:经临床对比研究分析可见,采用异丙酚麻醉药物对下腹部手术进行麻醉其对应激反应的控制明显优于异氟醚。

Objective： To analyze the effect of isoflurane and propofol anesthesia on stress reaction of lower abdominal operation during perioperative period.Method：140 patients with abdominal operation were collected in our hospital,they were divided into the isoflurane group and the propofol group for the average. The two groups were given isoflurane inhalation maintain anesthesia and maintain anesthetic propofol micro pump respectively,the index of the two groups were observed and compared.Result：The blood glucose and cortisol concentrations of the two groups were increased after anesthesia,and the isoflurane group increased obviously（P〈0.05）;while in MAP,HR contrast,the propofol group no significant statistical difference before and after anesthesia（P〉0.05）,and the isoflurane group in ten minutes after anesthesia decreased obviously（P〈0.05）. Compared with before anesthesia,the erythrocyte aggregation index,whole blood high shear viscosity,plasma viscosity of the isoflurane group were decreased after anesthesia（P〈0.05）,whole blood high shear viscosity was reduced in the propofol group only（P〈0.05）.Conclusion：The propofol anesthesia drugs on abdominal operation under anesthesia on the stress response of the control is better than that of isoflurane.