抗结核药致肝功能损伤的临床分析

Clinical Analysis on Anti-tb Drugs Cause Liver Damage

目的：探讨应用抗结核药物引起患者肝功能损伤的危险因素。方法：对2012年7月1日-2013年12月31日入住本院的128例肺结核患者临床资料进行回顾性分析，对应用抗结核药物导致肝功能损伤情况与患者年龄、吸烟嗜酒、既往病史、合并其他疾病，应用抗结核药物时间以及肺结核类型的关系进行分析。结果：应用抗结核药物导致肝功能损伤的时间多发生于用药2-6周；60岁以上患者发生肝功能损伤的几率明显高于60岁以下患者（P〈0.05）；有既往病史、嗜酒及粟粒型肺结核的患者发生肝功能损伤的几率较高（P〈0.05）。结论：年龄大、嗜酒、有既往病史等均为肺结核患者肝功能损伤的危险因素，这类人治疗强化期肝功能损伤更为严重，要早期诊断、及时治疗。

To explore the application of anti-tb drugs cause risk factors in patients with liver function injury. Method：Clinical data of 128 patients with pulmonary tuberculosis were retrospectively analyzed,and the application of anti-tb drugs cause liver damage and the patients＆#39; age,smoking,drinking,medical history,application time of anti-tb drugs and the relationship between pulmonary tuberculosis type were analyzed. Result：Application of anti-tb drugs cause liver damage 2-6 weeks time developed in drugs. Over 60 patients with liver injury were significantly higher than the risk of under 60 patients（P＆lt;0.05）. Medical history,drinking and millet in patients with tuberculosis of liver function damage probability were higher（P＆lt;0.05）. Conclusion：Age,alcohol,such as medical history are the risk factors of pulmonary tuberculosis patients with liver function injury,this kind of person treatment strengthen liver function injury is more serious,to early diagnosis and timely treatment.