牙周治疗对冠心病伴牙周炎患者血清HsCRP、TNF-α、IL-1β、IL-6水平的影响

The Effect of Periodontal Therapy on Serum HsCRP,TNF-α,IL-1β,IL-6 Level of Coronary Heart Disease Patients with Periodontitis

目的:探讨牙周治疗对冠心病伴牙周炎患者血清HsCRP、TNF-α、IL-1β、IL-6水平的影响。方法:选取2012年6月-2013年6月期间本院收治的95例冠心病伴牙周炎患者,均进行牙周综合干预,比较干预前与干预6个月后血清TNF-α,HsCRP、IL-6、IL-1β水平的变化及(牙周炎)附着水平改善的相关性。结果:治疗后患者血清TNF-α,HsCRP、IL-6、IL-1β水平均较治疗前显著降低,差异均有统计学意义(P<0.01);患者血清TNF-α,HsCRP、IL-6、IL-1β水平与(牙周炎)附着水平呈负相关,差异均有统计学意义(P<0.05)。结论:牙周治疗可有效降低冠心病伴牙周炎患者血清HsCRP、TNF-α、IL-1β、IL-6水平,且患者血清TNF-α、HsCRP、IL-6、IL-1β水平与(牙周炎)附着水平呈负相关,可在一定程度上预测患者牙周炎改善程度。

To investigate the effect of periodontal therapy on serum HsCRP,TNF-α,IL-1β,IL-6 level of coronary heart disease patients with periodontitis.Method：95 coronary heart disease patients with periodontitis were selected from June 2012 to June 2013 in our hospital during the period,all patients were given periodontal intervention.The serum TNF-α,HsCRP,IL-6,IL-1βlevel changes and（periodontitis）attachment level improved correlation were compared before the intervention and 6 months after intervention.Result：After treatment, the serum TNF-α,HsCRP,IL-6,IL-1β levels were decreased significantly,the differences were statistically significant（P〈0.01）,the serum TNF-α,HsCRP,IL-6,IL-1βlevels were negatively correlated with（periodontitis） attachment level,the differences were statistically significant（P〈0.05）.Conclusion：The periodontal treatment can effectively reduce serum HsCRP,TNF-α,IL-1β,IL-6 level of coronary heart disease patients with periodontitis, and serum TNF-α,HsCRP,IL-6,IL-1βlevels are negatively correlated with（periodontitis）attachment level,and to some extent can predict the degree of improvement in patients with periodontitis.