摘要
目的:探讨患者血清中血管生成因子2(Ang2)的浓度与慢性阻塞性肺病(COPD)之间的相关性。方法:分别收集50名COPD急性加重期患者,50名COPD稳定期患者和50名健康体检者外周血标本,用ELISA法检测血清中Ang2的浓度。结果:COPD急性加重期患者、COPD稳定期患者及健康体检者血清Ang2浓度分别是3861.6±273.8pg/ml、2107.4±843.4pg/ml和1645.7±453.2pg/ml。COPD急性加重期患者血清中Ang2浓度显著高于COPD稳定期患者及健康人(P<0.01)。结论:COPD急性加重期患者血清中Ang2浓度显著升高,Ang2可能成为评价COPD急性加重的一个有用的生物标记物。
To study the correlation between the serum angiopoietin -2 （Ang2 ） and chronic obstructive pulmonary diseases （COPD） .[Method] Serum concentration of Ang2 were measured by ELISA in 50 patients with COPD acute exacerba-tion ,50 patients with stable COPD and 50 healthy control subject .[Result] Serum Ang2 concentrations were 3861 .6 ＆#177; 273 . 8pg/ml in patients with COPD acute exacerbation ,2107 .4 ＆#177; 843 .4pg/ml in patients with stable COPD and 1645 .7 ＆#177; 453 .2 pg/ml in healthy control subject ,respectively .The concentration of serum Ang2 were significantly higher in patients with COPD a-cute exacerbation than in stable COPD patients and healthy control subjects （P＆lt;0 .01） .[Conclusion] Serum Ang2 concentra-tion was significantly increased in COPD acute exacerbation ,and it might be a potential biomarker for the evaluation of this dis-ease .
出处
《浙江医学教育》
2014年第4期49-51,共3页
Zhejiang Medical Education
