2型糖尿病患者骨密度和骨代谢100例临床研究

目的 分析2型糖尿病患者骨密度和骨代谢之间的联系。方法 选取郑州大学第一附属医院2012年2月~2013年4月收治的100例2型糖尿病患者（观察组）和在此期间进行健康体检人员100名（对照组）,分别对2组人员的骨密度及骨代谢情况进行测定,并根据性别和年龄情况对所有患者测定结果进行对比分析。结果 （1）BMD：40~60岁以上年龄组的2型糖尿病患者腰椎和股骨Ward区的骨密度与对照组数值接近,但50岁组和70岁以上年龄组骨密度明显低于对照组,差异有统计学意义（P〈0.05）;（2）骨代谢：观察组的BGP与DPD水平分别为（6.73±3.54）μg/L与（7.59±4.81）nmol/mmol,均明显高于对照组,差异有统计学意义（P〈0.01）。结论 2型糖尿病患者的骨形成减少,骨吸收增加,其骨密度丢失情况明显高于对照组,骨质疏松发生率要明显高于对照组,而且随着年龄的增加骨质疏松的发生率也随之增加。

Objective To analyze the relationship of bone mineral density and bone metabolism in patients with type 2 diabetes mellitus. Methods 30 cases patients with type 2 diabetes were selected in our hospital from February 2012 to April 2013 as the observation group, and also selected 30 healthy volunteers during this period as the control group. The bone mineral density and the bone metabolism of the two groups were measured, and the data were analyzed according to gender, age for all patients. Results （I） BMD： lumbar spine and femur BMD Ward and values of female with Type 2 diabetes patients in the 40-60 years old were close to the control group, but the 50-year-old group and the over 70 age group, BMD was significantly lower than the control group, with statistical significance （P〈0.05）; （2） bone metabolism ： the BGP and DPD levels of observation group were （6.73±3.54） μg/L and （7.59±4.81） nmol/mmol, which were significantly higher than those in the control group, with statistical significance （P〈0.01）. Conclusion Type 2 diabetes patients decreased bone formation increased bone resorption, which is significantly higher bone mineral density loss condition, the incidence of osteoporosis is significantly higher, and with the increasing age, the incidence of osteoporosis also increases.