2010年版中国药典含马钱子的中成药分析

An analysis of prepared TCM medicine containing Maqianzi in Chinese pharmacopoeia 2010 edition

目的:了解含马钱子中成药的剂型分布及入药的特点。方法:对2010年版《中国药典》收录的14个含有马钱子的中成药进行统计分析。结果:药典收载的14个含马钱子提取工艺的中成药中,马钱子直接打粉入药的占78.6%,功能主治上以活血化瘀、通经活络、理气止痛为主。结论:马钱子的主要活性成分为士的宁和马钱子碱,2010年版《中国药典》收载的含马钱子的中成药制剂制法与剂型均比较单一,马钱子在制剂中作用比较固定、缺乏变化,可知由于马钱子有大毒,临床上运用马钱子还是受到较大限制,因此应当多方面、多层次加大对马钱子配伍及炮制方法的研究,使马钱子的功效得到最大发挥。

Objective：To investigate formation and medication feature of prepared TCM medicine containing Maqianzi. Methods：14 prepared TCM medicine collected in Chinese pharmacopoeia 2010 edition were statistically analyzed. Results：78.6%of Maqianzi were powdered in 14 prepared TCM medicine, focusing on Huoxue Huayu, Tongjing Huoluo and Liqi Zhitong. Conclusion：Strychnine and brucine are the major active constituents of Maqianzi. Preparation and formation of prepared TCM medicine containing Maqianzi in Chinese pharmacopoeia 2010 edition were single;Maqianzi’s functions were unique and changeless. Clinical application of Maqianzi was confirmed due to strong toxicity. So compatibility and processing methods of Maqianzi should be studied in many ways and different levels for better effects.