氩离子凝固术配合埃索美拉唑治疗Barrett食管临床研究

A clinical study on treating Barrett's esophagus with argon plasma coagulation plus esomeprazole

目的:探讨内镜下氩离子凝固术(Argon Plasma Coagulation,APC)配合抑酸治疗Barrett食管(Barrett’s Esophagus,BE)的临床疗效。方法:在内镜下以APC对40例经病理证实为肠上皮化生的BE完全损毁化生黏膜,再配合埃索美拉唑抑酸治疗,术后再进行内镜、病理随访12个月。结果:40例均完成治疗,其中需要1次治疗者28例,2次治疗者11例,3次治疗者1例。37例达到完全的鳞状上皮再生(92.5%),3例再生的鳞状上皮间混有岛状的柱状上皮(7.5%),12个月后共有4例出现内镜下可见的复发。结论:内镜下APC配合抑酸治疗BE安全、有效,但有一定比例的复发和残留。

Objective： To study clinical effects of the argon plasma coagulation （APC） plus esomeprazole on Barrett＇s esophagus（BE）. Methods： 40 patients with Barrett＇s esophagus confirmed by endoscope were treated with APC and successively acid suppression therapy. All the patients were rechecked by endoscope and pathology method on 12 months after treatment. Results： All patients were accomplished treatment. The eradication was obtained in 28 cases by only one session and 11 cases two session, 1 cases three sessions. The complete squamous reepithelialization was observed in 37 patients （92.5%）, and remnant islands of columnar epithelium mixed with squamous reepithelialization in the original places were observed in 3 patients （7.5%）. The reappearance of columnar epithelium was observed in 4 patients in 12 months. Conclusion： APC plus esomeprazole in Barrett＇s esophagus＇ endepidermis show obvious reversal function, however, recurrences and residual of BE are present in minority of oatients.