摘要
Objective: The purpose of the study wass to explore the correlation between thyroid function and nodular goiter accompanied with gallstone. Methods: We collected 120 cases about nodular goiter accompanied with gallstone and 128 cases about nodular goiter and establish 50 healthy control groups. Detected t level of hyrotropic hormone(TSH), total triiodothyronine(TT3), total thyroxine in the peripheral venous blood of these cases in the three groups by using electrochemiluminescence immunoassay, measure level of total cholesterol(TC), high-density lipoprotein cholesterol(HDL-C), low-density lipoprotein cholesterol(LDL-C) and total bile acid(TBA) levels by using enzymic method, and observed the changes of thyroid function and blood lipid among the three groups. Results: The serum TT3 level in nodular goiter accompanied with gallstone group and the nodular goiter group was significantly lower than that in control group(P < 0.01), and TSH level in the nodular goiter accompanied with gallstone group is significantly higher than that in control group(P < 0.01). There were no statistical significance about difference of TT4 level among the three groups(P > 0.05). Accordingly, TC and LDL-C level in nodular goiter accompanied with gallstone group was significantly higher than that in nodular goiter and control group(P < 0.01), while TBA level in nodular goiter accompanied with gallstone group was significantly lower than that in simple nodular goiter group and control group(P < 0.01). There was no statistical significance about difference of TC and LDL-C level between simple nodular goiter group and control group(P > 0.05). The HDL-C level in nodular goiter accompanied with gallstone group and control group was higher than that in simple nodular goiter group(P < 0.01). Conclusion: The originating etiologic factor of nodular goiter accompanied with gallstone may be related to that the decreased TT3 induced sub-clinical hypothyroidism.
Objective: The purpose of the study wass to explore the correlation between thyroid function and nodular goiter accompanied with gallstone. Methods: We collected 120 cases about nodular goiter accompanied with gallstone and 128 cases about nodular goiter and establish 50 healthy control groups. Detected t level of hyrotropic hormone (TSH), total triio- dothyronine (TT3), total thyroxine in the peripheral venous blood of these cases in the three groups by using electrochemilu- minescenca immunoassay, measure level of total cholesterol (TC), high-density tipoprotein cholesterol(HDL-C), low-density lipoprotein cholesterol (LDL-C) and total bile acid (TBA) levels by using enzymic method, and observed the changes of thyroid function and blood lipid among the three groups. Results: The serum TT3 level in nodular goiter accompanied with gallstone group and the nodular goiter group was significantly lower than that in control group (P 〈 0.01), and TSH level in the nodular goiter accompanied with gallstone group is significantly higher than that in control group (P 〈 0.01), There were no statistical significance about difference of TT4 level among the three groups (P 〉 0.05). Accordingly, TC and LDL-C level in nodular goiter accompanied with gallstone group was significantly higher than that in nodular goiter and control group (P 〈 0.01), while TBA level in nodular goiter accompanied with gallstone group was significantly lower than that in simple nodular goiter group and control group (P 〈 0.01). There was no statistical significance about difference of TC and LDL-C level between simple nodular goiter group and control group (P 〉 0.05). The HDL-C level in nodular goiter accompanied with gallstone group and control group was higher than that in simple nodular goiter group (P 〈 0.01). Conclusion: The originating etiologic factor of nodular goiter accompanied with gallstone may be related to that the decreased TT3 induced sub-clinical hypothyroidism.