摘要
Objective: Stent placement is one of the main methods in the palliative treatment of malignant biliary obstruction, including plastic and self-expandable metal stents. The comparison of stent patency between self-expandable metal and plastic stents in palliation of malignant biliary obstruction is meaningful. We carried out a meta-analysis to summarize current evidence for clinical efficacy of self-expandable metal and plastic stents in the treatment of malignant biliary obstruction. Methods: A comprehensive search of several databases including CNKI, Wanfang Data, Sino MED. A fixed-effects or random-effects model was used to pool data of all study endpoint. Sensitivity analysis was also performed. Results: Eight randomized clinical trials were identified, including 633 patients. These results suggested that the self-expandable metal stents were associated with a significantly longer stent patency(OR = 8.15; 95% CI: 2.80–23.76; I2 = 85%). No publication bias was observed. Conclusion: Self-expanding metal stents have a longer patency than plastic stents and offer adequate palliation in patients with malignant biliary obstruction.
Objective： Stent placement is one of the main methods in the palliative treatment of malignant biliary obstruc- tion, including plastic and self-expandable metal stents. The comparison of stent patency between self-expandable metal and plastic stents in palliation of malignant biliary obstruction is meaningful. We carried out a meta-analysis to summarize current evidence for clinical efficacy of self-expandable metal and plastic stents in the treatment of malignant biliary obstruc- tion. Methods： A comprehensive search of several databases including CNKI, Wanfang Data, Sino MED. A fixed-effects or random-effects model was used to pool data of aU study endpoint. Sensitivity analysis was also performed. Results： Eight randomized clinical trials were identified, including 633 patients. These results suggested that the self-expandable metal stents were associated with a significantly longer stent patency （OR = 8.15; 95% CI： 2.80-23.76; 12 = 85%）. No publication bias was observed. Conclusion： Self-expanding metal stents have a longer patency than plastic stents and offer adequate palliation in patients with malignant bUiary obstruction.
