期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

PRMT1精氨酸甲基化作用的研究进展

The Progress of PRMT1-mediated Arginine Methylation
下载PDF
导出
摘要 PRMT1属于Ⅰ型PRMT酶,分子大小约40 kDa,常以大分子复合体形式发挥作用。其底物分子众多,酶活性受多因素调节。PRMT1参与了细胞信号转导、DNA损伤修复、转录调节、RNA代谢、蛋白质相互作用等多种细胞过程。PRMT1与多种癌性疾病及非癌性疾病有关。 PRMT1 belongs to typeⅠPRMTs,and the molecular weight is approximately 40 kDa,which usually form the macromolecular complexes. PRMT1 involves in many biological processes such as the regulation of gene transcription,chromatin remodeling,cellular signal transduction and the repair of DNA damage,RNA metabolism and protein interactions.PRMT1 are associated with a variety of cancerous and non cancerous disease.
作者 李晨燕 冯秋菊
机构地区 西安市卫生学校
出处 《中外医学研究》 2014年第24期157-158,共2页 CHINESE AND FOREIGN MEDICAL RESEARCH
关键词 PRMT1 精氨酸甲基化 细胞过程 PRMT1 Arginine methylation Cellular process
分类号 R3411 [医药卫生—基础医学]
  • 相关文献

参考文献20

  • 1Bedford M T.Arginine methylation at a glance[J].Cell Sci, 2007, 120(Pt 24): 4243-4246.
  • 2Lin W J, Gary J D, Yang M C, et al.The mammalian immediate-early TIS21 protein and the leukemia-associated BTG1 protein interact with a protein-arginine N-methyhransferase[J].Biol Chem, 1996, 271(25): 15034-15044.
  • 3Robin-Lespinasse Y, Sentis S, Kolytcheff C, et al.hCAF1, a new regulator of PRMTl-dependent arginine methylation[J].Cell Sci, 2007, 120(4): 638-647.
  • 4Miyata S, Mori Y, Tohyama M.PRMTI and Btg2 regulates neurite outgrowthof Neuro2a cells[J].Neurosci Lett, 2008, 445(3): 162-165.
  • 5谢萍,田春艳,张令强,安利国,贺福初.组蛋白甲基转移酶的研究进展[J].遗传,2007,29(9):1035-1041. 被引量：12
  • 6Liu Q, Dreyfuss G.In vivo and in vitro arginine methylation of RNA- bindingproteins[J].Mol Cell Biol, 1995, 15(5): 2800-2808.
  • 7Boisvert F M, Chenard C A, Richard S.Protein interfaces in signaling regulated by arginine methylation [J].Sci STKE, 2005, 271(2): 1-10.
  • 8Adams M M, Wang B, Xia Z, et al.53BPloligomerization is independent of its methylation by PRMTI[J].Cell Cycle, 2005, 4(1): 1854-1861.
  • 9Yu Z, Chen T, Hebert J, et al.A mouse PRMT1 null allele defines an essential role for arginine methylation in genome maintenance and cell proliferation[J].Mol Cell Biol, 2009, 29(11): 2982-2986.
  • 10Chevillard-Briet M, Trouche D, Vandel L.Control of CBP co-activating activity by arginine methylation[J].EMBO J, 2002, 21(20): 5457-5466.

二级参考文献60

  • 1Jaskelioff M,Peterson CL.Chromatin and transcription:histones continue to make their marks.Nat Cell Biol,2003,5(11):395-399.
  • 2Fischle W,Wang Y,Allis CD.Histone and chromatin cross-talk.Curr Opin Cell Biol,2003,15:172-183.
  • 3Lachner MO,Sullivan RJ,Jenuwein T.An epigenetic road map for histone lysine methylation.J Cell Sci,2003,116(10):2117-2124.
  • 4Qian C,Zhou MM.SET domain protein lysine methyltransferases:Structure,specificity and catalysis.Cell Mol Life Sci,2006,63(23):2755-2763.
  • 5Martin C,Zhang Y.The diverse functions of histone lysine methylation.Nat Rev,2005,6(11):838-849.
  • 6Seligson DB,Horvash S,Shi T.Global histone modification patterns predict risk of prostate cancer recurrence.Nature,2005,435(7046):1262-1266.
  • 7Wilson J,Jing C,Walker P,Martin S,Howell S,Blackburn G,Gamblin S,Xiao B.Crystal structure and functional analysis of the histone methyltransferase SET7/9.Cell,2002,111(1):105-115.
  • 8Xiao B,Jing C,Wilson JR,Walker PA,Vasisht N,Kelly G,Howell S,Taylor IA,Blackburn GM,Gamblin SJ.Structure and catalytic mechanism of the human histone methyltransferase SET7/9.Nature,2003,421(6923):652-656.
  • 9Trievel RC,Beach BM,Dirk LM,Houtz RL,Hurley JH.Structure and catalytic mechanism of a SET domain protein methyltransferase.Cell,2002,111(1):91-103.
  • 10Taylor WR,Xiao B,Gamblin SJ,Lin K.A knot or not a knot? SETting the record 'straight' on proteins.Comput Biol Chem,2003,27(3):11-15.

共引文献14

中外医学研究
2014年 第24期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部