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黑米花青素抑制HER-2阳性乳腺癌细胞转移的研究 被引量:6

Effects of Black Rice Anthocyanins on Metastasis of HER-2 Positive Human Breast Cancer Cells
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摘要 乳腺癌是女性最常见恶性肿瘤之一,位列20-59岁女性致死性癌症首位[1]。WHO公布数据显示,2011年全世界乳腺癌占女性癌症诊断病例(138万例)的23%,死亡病例(45.8万例)的14%,约90%患者均死于癌细胞转移[2-3]。Nahta等通过FISH(fluorescent in situ hybridization,荧光原位杂交)方法检测出47%乳腺癌患者HER-2基因过量表达,
出处 《营养学报》 CAS CSCD 北大核心 2014年第4期392-394,共3页 Acta Nutrimenta Sinica
基金 国家自然科学基金(No.81273074) 成都医学院科研基金(No.CYZ12-015) 成都医学院学科建设项目(No.CYXK2012010)
关键词 乳腺癌 转移 人表皮生长因子受体 花青素 breast cancer metastasis human epidermal growth factor receptor anthocyanins
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参考文献8

  • 1Siegel R, NaishadhamD, Jemal A. Cancer Statistics, 2012 [J]. CA Cancer J Clin, 2012, 62: 10-29.
  • 2Jemal A, Bray F, Center MM, et al. Global cancer statistics [J]. CA Cancer J Clin, 2011, 61: 69-90.
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  • 6于斌,余小平,易龙,常徽,陈春烨,金鑫,糜漫天.黑米花青素对HER-2/neu高表达人乳腺癌细胞株MDA-MB-453移植瘤血管生成的影响[J].第三军医大学学报,2009,31(22):2206-2209. 被引量:9
  • 7于斌,余小平,易龙,朱俊东,张乾勇,糜漫天.黑米花色苷抑制人乳腺癌细胞促血管生成因子表达的机制[J].营养学报,2010,32(6):545-550. 被引量:18
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二级参考文献18

  • 1王庆,郭红辉,张名位,夏效东,邓斌,夏敏,凌文华.高效液相色谱法分析黑米皮花青素及其体内代谢产物[J].食品科学,2006,27(5):212-215. 被引量:20
  • 2张名位,张瑞芬,郭宝江,池建伟,魏振承,徐志宏.黑米花色苷对血管内皮细胞过氧化损伤的保护作用[J].营养学报,2006,28(3):216-220. 被引量:30
  • 3Wang L S, Stoner G D. Anthocyanins and their role in cancer prevention[J]. Cancer Lett, 2008, 269(2): 281 -290.
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  • 6Lamy S, Ruiz M T, Wisniewski J, et al. A prostate secretory protein94-derived synthetic peptide PCK3145 inhibits VEGF signalling in endothelial cells: implication in tumor angiogenesis[ J]. Int J Cancer, 2005, 118(9) : 2350 -2358.
  • 7Grummer M A, Sullivan J A, Magness R R, et al Vascular endothelial growth factor acts through novel, pregnancy-enhanced receptor signalling pathways to stimulate endothelial nitric oxide synthase activity in uterine artery endothelial cells [ J ]. Biochem J, 2009, 417 (2) : 501 -511.
  • 8Lamy S, Blanchette M, Michaud-Levesque J, et al. Delphinidin, a dietary anthocyanidln, inhibits vascular endothelial growth factor receptor-2 phosphorylation [ J ]. Carcinogenesis, 2006, 27 (5) : 989 - 996.
  • 9Chen P N, Kuo W H, Chiang C L, et al. Black rice anthoeyanins inhibit cancer cells invasion via repressions of MMPs and u-PA expression[J]. Chem Biol Interact, 2006, 163(3) : 218 -229.
  • 10Rakesh Kumar, Rozita Yarmand-Bagheri. The role of HER2 in angiogenesis[J]. Semin Oncol, 2001, 28: 27-32.

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