我院2009-2013年左氧氟沙星使用强度与医院内病原菌耐药率相关性分析

Analysis of the Correlation of Levofloxacin Use Intensity with Resistance Rates of Nosocomial Pathogens in Our Hospital from 2009 to 2013

目的:研究左氧氟沙星使用强度与医院内病原菌耐药率的相关性,为提高临床合理用药水平、控制病原菌对左氧氟沙星耐药性的增长提供依据。方法:回顾性分析我院2009-2013年左氧氟沙星的使用强度和同期5种病原菌对左氧氟沙星的耐药率,用SPSS软件分析两者的相关性。结果:左氧氟沙星的使用强度与铜绿假单胞菌的耐药率有相关性(P<0.05),与鲍曼不动杆菌的耐药率呈显著相关(P<0.01),与大肠埃希菌、肺炎克雷伯菌、嗜麦芽假单胞菌的耐药率的相关性无统计学意义(P>0.05)。结论:左氧氟沙星逐年增长的高使用强度导致了病原菌耐药率的升高,增大了临床治疗感染性疾病的难度。抗菌药物的合理使用是控制和治疗院内感染的关键和重要措施。

OBJECTIVE： To study the correlation of levofloxacin use intensity with resistance rates of nosocomial pathogens, and to provide theoretical basis for promoting the rational use of drugs and controlling the increase of pathogens resistant to levofloxacin. METHODS ： The levofloxacin use intensity and resistance rate of 5 kinds of pathogens to levofloxacin were analyzed retrospectively during 2009--2013. The correlation of them was analyzed by using SPSS software. RESULTS： The levofloxacin intensity use was correlated with resistance rate of Pseudomonas aeruginosa （P〈0.05）, and significantly correlated with resistance rate of Acinetobacter baumannii （P〈0.01）. There was no significant correlation between levofloxacin intensity use and drug resistance of Escherichia coli, Klebsiella pneumoniae and Pseudomonas maltophilia. CONCLUSIONS： The high use intensity of levofloxacin increases year by year, which leads to the increase of pathogen resistance and the difficulty of infectious diseases therapy. Rational use of antibiotics is critical and important measures for control and treatment of nosocomial infections.