摘要
OBJECTIVE: To investigate the effects of Yiqibushenhuoxue decoction on stable chronic obstructive pulmonary disease(COPD) by observing its influences on patients' quality of life and airway inflammation.METHODS: Seventy patients with stable COPD were randomly divided into a treatment group(n=35) treated with Yiqibushenhuoxue decoction plus Seretide and a control group(n=35) treated with Seretide only.The dosage of Yiqibushenhuoxue decoction was 100 mL each time, twice a day, and the dosage of Seretide was salmeterol 50 μg/fluticasone 250 μg twice a day. Both groups were treated for 12 weeks. Before and after the treatment, St George's respiratory disease questionnaire(SGRQ)scores,forced expiratory volume,and forced expiratory volume in 1 second/forced vital capacity(FEV1/FVC)were measured.RESULTS:The SGRQ scores in both groups were significantly lower than those before treatment(P<0.05). After treatment, the total SGRQ scores and each subscore in the treatment group were significantly lower than those in the control group(P<0.05). The percentage of the predicted FEV1% and FEV1/FVC were higher in both groups, but no statistical differences were detected from before to after the treatment or between the two groups(P>0.05).CONCLUSION: Yiqibushenhuoxue decoction could significantly decrease the SGRQ scores in patients with stable COPD, which suggests that it is able to improve patient symptoms.
OBJECTIVE： To investigate the effects of Yiqibushenhuoxue decoction on stable chronic obstructive pulmonary disease（COPD） by observing its influences on patients＇ quality of life and airway inflammation.METHODS： Seventy patients with stable COPD were randomly divided into a treatment group（n=35） treated with Yiqibushenhuoxue decoction plus Seretide and a control group（n=35） treated with Seretide only.The dosage of Yiqibushenhuoxue decoction was 100 mL each time, twice a day, and the dosage of Seretide was salmeterol 50 μg/fluticasone 250 μg twice a day. Both groups were treated for 12 weeks. Before and after the treatment, St George＇s respiratory disease questionnaire（SGRQ）scores,forced expiratory volume,and forced expiratory volume in 1 second/forced vital capacity（FEV1/FVC）were measured.RESULTS：The SGRQ scores in both groups were significantly lower than those before treatment（P〈0.05）. After treatment, the total SGRQ scores and each subscore in the treatment group were significantly lower than those in the control group（P〈0.05）. The percentage of the predicted FEV1% and FEV1/FVC were higher in both groups, but no statistical differences were detected from before to after the treatment or between the two groups（P〉0.05）.CONCLUSION： Yiqibushenhuoxue decoction could significantly decrease the SGRQ scores in patients with stable COPD, which suggests that it is able to improve patient symptoms.
基金
Supported by a Planned Project of Cultivating Innovative Personnel Fund of Heilongjiang University of Chinese Medicine
Chunhui Planning Project Fund of Chinese Ministry of Education(No.Z2010045)
