伴有中央颞区棘波的小儿良性癫（痫）的始发年龄与语言障碍关系的研究

Association of language dysfunction and age of onset of benign epilepsy with centrotemporal spikes in children

目的 评价伴有中央颞区棘波的小儿良性癫（痫）（benign epilepsy with centrotemporal spikes in children,BECTS）的始发年龄与语言障碍的关系.方法 分别对63例BECTS患儿和30名对照组儿童应用韦氏儿童智力测试（C-WISC）的子测验言语部分进行语言功能的评估.结果 所有63例BECTS患儿的语言检测均较30名对照组儿童差.其中初始发病年龄小于6岁患儿的语言检测尤为差（语言检测总分39.21＆#177;1.40）,与发病年龄≥6岁的患儿（语言检测总分44.48 ＆#177;2.23）比较,语言功能检测差异有统计学意义（P＜0.05）;语言功能与癫（痫）持续时间、惊厥次数、治疗状态和中央颞区棘波偏侧或双侧均无明显相关性（P＞0.05）;语言功能与始发年龄有明显相关性（P＜0.05）.结论 BECTS始发年龄小的儿童的语言功能较差,始发年龄偏大的儿童的语言功能相对较高,但较对照组儿童的语言表达功能差.BECTS始发年龄可以较好地预测语言功能.

Objective To assess language function in children with benign epilepsy with centrotemporal spikes in children（BECTS） and its association with the age of epilepsy onset.Methods We assessed language function in 63 children with BECTS and 30 age and sex matched controls by the subtest of CWISC.Results Children with BECTS performed significantly worse on all language tasks as compared to controls and overall better language function was positively correlated with older age of the child.Early age at seizure onset demonstrated significant negative correlation with language dysfunction,age below 6 years being related to the lowest performance scores（P 〈 0.05）.There was no relationship between the language function and the laterality of epileptic focus,seizure treatment status,or the duration of epilepsy（P 〉 0.05）.There was significant relationship between the language dysfunction and onset age of epilepsy （P 〈 0.05）.Conclusion Children with BECTS have language difficulties that are more pronounced in younger age group.Despite better language functioning in older children with BECTS,their verbal abilities remain inferior to those of children without epilepsy.Early age at seizure onset is a significant factor predicting worse language functioning in children with BECTS.