乳腺癌组织中TGFβ_1、VEGF、c-erbB-2的表达及其与浸润转移的关系

A Study on Relationships Between TGFβ_1、VEGF、c-erbB-2 Expression and the Invasion and Metastasis of Breast Cancer

目的 探讨转化生长因子 β1、血管内皮生长因子及c -erbB -2在乳腺癌组织中的表达及其与浸润转移的关系。方法 采用免疫组化EnVisionTM二步法检测 6 5例乳腺癌组织中TGFβ1、VEGF、c -erbB -2的表达情况。结果 TGFβ1、VEGF、c -erbB -2的表达均与乳腺癌淋巴结转移密切相关 (P <0 .0 5或P <0 .0 1) ,TGFβ1表达还与癌浸润相关 (P <0 .0 1) ;VEGF表达与TGFβ1、c -erbB -2表达呈显著正相关 (P均 <0 .0 1)。结论 TGFβ1、VEGF和c -erbB -2的过度表达预示着乳腺癌具有较强的转移能力 ;3种蛋白的过度表达可能在乳腺癌的浸润转移过程中起协同作用。

Objective To study the expressions of TGFβ 1?VEGF?c-erbB-2 in breast cancer,and the relationship between them and the cancer invasion and metastasis.Methods The expressions of TGFβ 1?VEGF and c-erbB-2 were investigated in 65 cases of breast cancer by EnVision TM immunohistochemical staining.Results The expressions of TGFβ 1?VEGF and c-erbB-2 were all correlated to tumor metastasis(P<0.05 or P<0.01);as well as TGFβ 1 expression was correlated to tumor invasion(P<0.01).There was a striking association between the expression of VEGF and the expressions of TGFβ 1 or c-erbB-2(P<0.01 or P<0.01).Conclusion TGFβ 1?VEGF and c-erbB-2 may be involved in metastasis of breast cancer.The overexpressions of them indicate stronger metastasis potential of breast cancer.The overexpressions of these three proteins may coexist in the invasion and metastasis of breast cancer.