动态观察急性脑梗死患者血清S100B蛋白的表达与神经功能缺损程度的关系

Dynamic observation of serum S100B protein expression in patients with acute cerebral infarction and its relation with the degree of nervous function defect

目的研究急性脑梗死(ACI)患者血清特异性神经元烯醇化酶(NSE)与内皮素(ET)以及S100B蛋白的表达,在急性期变化中同神经功能缺损程度之间的关系。方法回顾性分析2008年5月至2012年5月治疗的90例ACI患者临床资料(观察组),以及同时期治疗的62例非神经系统类疾病患者临床资料(对照组),对比分析两组患者神经功能缺损程度以及血清NSE、ET、S100B蛋白的表达情况。结果观察组患者血清的NSE、ET、S100B蛋白的表达同对照组相比,均呈不同程度的增高,差异有统计学意义(P<0.01);观察组不同神经功能缺损的评分分型的患者血清NSE、ET以及S100B蛋白的表达,差异有统计学意义(P<0.01)。结论 ACI患者血清的NSE、ET以及S100B蛋白表达,与神经功能缺损程度具有密切关系,当神经功能缺损的程度越重,患者血清的NSE、ET以及S100B蛋白的水平就越高,因此三项指标能够作为ACI患者脑损伤的一种敏感标记物;可以作为对患者病情进行判断、对预后进行评估的重要指标,并且非常适合不能够予以影像学诊断的ACI患者。

Objective To study the expression of serum NSE （neuron specific enolase） and ET （endothelin） and S100B protein in patients with ACI （caute cerebral infarction ,and get the relation between the degree of neural function defect in the acute stage .Methods Retrospective analysis of our hospital from 2008 May to 2012 May ,clini-cal data of 90 patients with ACI treated in our department （observation group） ,and the same period of treatment of 62 cases of non nervous system disease in patients with clinical data （control group） ,comparative analysis of NSE and ET of two groups of nerve function defect degree ,serum ,and the expression of S100B protein .Results Observation of NSE and ET in serum ,and the expression of S100B protein compared with control group ,both groups were in-creased in different degree ,difference was significant（P 〈 0 .01）;to observe the degree of neural function defect pa-tients ,with serum NSE and ET ,and the expression of S100B protein ,showed significant difference（P〈0 .01） .Con-clusion NSE and ET in the sera of ACI patients ,and the expression of S100B protein ,has a close relationship with the degree of neural function defect ,the defect degree of the nervous function more weight ,NSE and ET in serum , and the content of S100B protein is higher ,so the three indicators can be a sensitive marker for brain damage in ACI patients ;it can be used to judge the patient′s condition ,evaluate the prognosis ,and is very suitable for those can not be imaging diagnosis of ACI patients .