衍射增强成像的肝脏组织微观可视化研究

Research of microscopic visualization of liver tissue using diffraction enhanced imaging

目的:探讨衍射增强成像的肝脏组织微观可视化研究。方法:采用在日本光子工厂获得的实验数据,利用滤波反投影法重建肝脏的断层图像,并且对图像进行去噪、增强、消除环状伪影、剪切等处理。此外,选取2种不同的肝纤维化模型的衍射增强图像,计算感兴趣区的纹理测度,并进行分析。结果:四氯化碳诱发的肝纤维化与白蛋白诱发的肝纤维化的衍射增强图像的纹理测度惯量、相关、和的均差确实存在差异,在一定程度上反映了2种物质诱发肝纤维化的不同。结论:衍射增强图像可以清晰地显示肝纤维化的组织纹理特征,是一种很好的X线成像技术。

Objective To study diffraction enhanced imaging （DEI） applied for the microscopic visualization of liver tissue. The slice images were reconstructed according to data from Photon Factory in Japan using filtered backprojection method and then several process steps were performed, such as denoising, enhancement, ring artifacts elimination and cutting. The DEI images of two kinds of fibrous liver were chosen as samples, and the texture measurements of region of interest were calculated respectively for analysis. Results The hepatic fibrosis induced by carbon tetrachloride had the DEI images significantly different from those of the hepatic fibrosis by albumin in texture measurement inertia, relevance and etc, and then the differences between the two hepatic fibroses were showed partly. Conclusion The diffraction enhanced image can clearly show the tissue texture features of liver fibrosis, and is a kind of effective X-ray imaging technology.