桐乡市恶性肿瘤危险因素病例对照研究

A case-control study on risk factors of malignant tumors in Tongxiang city

目的探讨精神心理、职业和饮食习惯对恶性肿瘤发病的影响程度,为制定恶性肿瘤的预防策略提供科学依据。方法调查2010—2012年新发恶性肿瘤患者2 471人,按性别相同、年龄±5岁1∶1匹配选取健康人群2 471人。调查数据采用单因素和多因素条件Logistic回归进行分析。结果单因素条件Logistic回归分析检出12个相关因素。多因素条件Logistic回归分析显示有害职业史(OR=1.731,95%CI:1.337～2.242)、常吃腌制蔬菜、煎炸烹饪(OR=1.889,95%CI:1.398～2.551)、重盐饮食(OR=1.457,95%CI:1.169～1.818),婚姻生活差(OR=2.007,95%CI:1.111～3.623)、精神压抑(OR=1.274,95%CI:1.003～1.617)和缺乏自我调节(OR=1.460,95%CI:1.189～1.793)等7项因素为恶性肿瘤的独立危险因素,与恶性肿瘤发病有关。结论桐乡市恶性肿瘤的发病与多种暴露因素有关,精神心理因素已成为重要的危险因素之一。

Objective To exam the influence of psychological factors,occupational factors and dietary habits on malignant tumors.Methods A total of 2 471 patients with malignant tumor were selected from 2010 to 2012 and 1 to 1 matching method was used controlling sex and age distribution in the case and control groups.Data collected by interviewing was analyzed by univariate and multivariate conditional logistic regression.Results 12 related factors including 6 psychological factors were found in relation to malignant tumor after univariate logistic regression analysis.The multivariate logistic regression analysis showed that harmful occupational history （OR =1.731,95%CI：1.337 ~2.242）,often having fried food （OR =1.889,95%CI：1.398 ~2.551）,heavy salty diet（OR =1.457,95%CI：1.169 ~1.818）,psychological problems （OR =1.274,95%CI：1.003 ~1.617）,poor marital life （OR =2.007,95%CI：1.111 ~3.623）and lack of self -regulation （OR =1.460,95%CI：1.189 ~1.793 ）were the risk factors.Conclusion Malignant tumor was related to a variety of exposure factors and psychological factor has become an important risk factor for malignant tumor in Tongxiang city.