摘要
目的不同品系的鸭对禽流感(AI)疫苗诱导的效价有差异,分析这种差异是否与主要组织相容性复合体(MHC)有关。方法用表达H5亚型禽流感HA基因重组鸭瘟活载体疫苗免疫抗原提呈相关转运体TAP基因等位基因型不同的4种SPF鸭,比较其血清HI动态变化。结果免疫后连续观察的9周中,B3群SPF鸭HI抗体效价始终显著高于另外3个群。结论鸭的不同MHC单倍型可能与AI疫苗的不同免疫效力相关。
Objective Different species of ducks respond differently to AIV vaccination.To investigate whether the different response to AIV vaccination is related with different species of ducks with MHC genetic background.Method In this study,four haplotypes determined by TAP gene alleotypes located in MHC loci of SPF ducks were used to compare HI titers changes post vaccination with recombinant live attenuated H5 avian influenza vaccine.Result The result showed that B3 haplotype SPF ducks produced significantly higher HI antibody titers than others during the 9 wks experiment.Conclusion These results hints that duck MHC genetics may affect the immune responses to AIV vaccination.
出处
《实验动物科学》
2014年第3期30-32,共3页
Laboratory Animal Science
基金
国家自然科学基金(No.31101800)
国家科技支撑课题(No.2013BAK11B02)
