磷霉素时间差疗法治疗难治性肺炎63例疗效评价

Practice and Experience of Time Difference Therapy in Treating Refractory Pneumonia on 63 Cases

目的探讨磷霉素联合其他抗菌药物的时间差疗法治疗难治性肺炎的疗效,并分析磷霉素的作用特点。方法将126例难治性肺炎患者随机分为A组、B组,各63例。A组采用磷霉素联合其他抗菌药物的时间差疗法,B组采用磷霉素联合其他抗菌药物的传统序贯疗法。结果 A组的治愈率为92.06%,B组为76.19%;A组平均起效时间、平均治愈时间及细菌清除率均优于B组(P<0.05)。结论磷霉素联合其他抗菌药物的时间差疗法治疗难治性肺炎安全有效,不良反应少且轻微。

Objective To investigate the effect of the time difference therapy of fosfomycin combined with other antibacterial drugs in the treatment of refractory pneumonia and to analyze the characteristics of phosphomycin. Methods 126 patients with refractory pneu- monia were randomly divided into the group A and B,63 cases in each group. The group A was treated by the time difference therapy of fosfomycin in combination with other antibacterial agents, while the group B adopted the traditional sequential therapy of fosfomycin in combination with other antibiotics. Results The cure rate was 92.06% in the group A and 76. 19% in the group B;the average initial effect time,cure time and the bacterial clearance rate in the group A were superior to those in the group B with statistical differences （P 〈 0. 05）. Conclusion The time difference therapy of fosfomycin combined with other antibacterial drugs is safe and effective and has few and mild adverse reaction for treating refractory pneumonia.