复方参芪维E胶囊联合泛昔洛韦对带状疱疹患者免疫功能的影响

Effect of Compound Shenqi Vitamin E Capsules Combined with Famciclovir on Immune Function in Patients with Herpes Zoster

目的探讨复方参芪维E胶囊联合泛昔洛韦对带状疱疹患者免疫功能的影响。方法将124例患者随机分为两组,各62例。对照组患者应用泛昔洛韦治疗,同时肌肉注射干扰素α-2b,持续用药7 d;观察组开始用药同对照组,停药后口服复方参芪维E胶囊,持续用药10 d。对比分析两组患者临床疗效及症状缓解时间,治疗前后应用流式细胞仪测定两组T淋巴细胞亚群。结果观察组总有效率为93.55%,明显高于对照组的77.42%(P<0.05)。观察组止疱、结痂、疼痛缓解、脱痂时间均明显短于对照组(P<0.05)。观察组治疗后CD+3,CD4+,CD4+/CD+8水平显著高于对照组,而CD+8水平则低于对照组(P<0.05)。观察组后遗神经痛发生率为0(0/62),低于对照组的8.06%(5/62),两组比较有统计学差异(P<0.05)。结论复方参芪维E胶囊联合泛昔洛韦治疗带状疱疹,能有效提高疗效,缓解临床症状,且能有效预防后遗神经痛的发生,同时可提高患者的免疫功能。

Objective To investigate the effect of Compound Shenqi Vitamin E Capsules combined with famciclovir on the immune function in the patients with herpes zoster. Methods 124 cases of herpes zoster were randomly divided into the observation group（ n = 62） and the control group（ n =62）. The control group simuhaneously applied famcielovir and intramuscular injection of interferon for continuous 7 d; while at the beginning the medication in the observation group was same to the control group, after drug withdrawal oral Compound Shenqi Vitamin E Capsules was given for continuous 10 d. The clinical effects and the symptom remission time were compared between the two groups. The levels of CD2 T lymphocyte subsets before and after treatment in the two groups were detected by the flow cytometry. Results The total effective rate of observation group was 93.55% ,which was higher than 77.42% in the control group,the difference had statistical significance（P 〈 0.05）. The time of blister stop,crusting time,pain relief time and decrustation time in the observation group were shorter than those in the control group（P 〈 0. 05）. The levels of CD;,CD4＋ and CD4＋/CD8＋ in the ob- servation group were significantly higher than those in the control group,while the level of CD8＋ was lower than that in the control group （P 〈 0. 05）. The incidence rate of postherpetic neuralgia in observation group was 0. 00% （0/62）,which was lower than 8.06% （5/62） in the control group,there was statistically significant difference between the two groups（P 〈 0. 05）. Conclusion Compound Shenqi Vtamin E Capsule combined with famciclovir in treating herpes zoster can improve the curative effect, alleviate the clinical symptoms,effectively prevent the occurrence of postherpetic neuralgia and simultaneously increase the patient＇s immune function.